1.Centers for Disease Control and Prevention. Vital signs: central line-associated blood stream infections—United States, 2001, 2008, and 2009. Morb Mortal Wkly Rep 2011;60:243–248.
2.Mermel, LA, McCormick, RD, Springman, SR, Maki, DG. The pathogenesis and epidemiology of catheter-related infection with pulmonary artery Swan-Ganz catheters: a prospective study utilizing molecular subtyping. Am J Med 1991;91:197S–205S.
3.Linares, J, Sitges-Serra, A, Garau, J, Perez, JL, Martin, R. Pathogenesis of catheter sepsis: a prospective study with quantitative and semiquantitative cultures of catheter hub and segments. J Clin Microbiol 1985;21:357–360.
4.Almirall, J, Gonzalez, J, Rello, J, et al. Infection of hemodialysis catheters: incidence and mechanisms. Am J Nephrol 1989;9:454–459.
5.Cheesbrough, JS, Finch, RG, Burden, RP. A prospective study of the mechanisms of infection associated with hemodialysis catheters. J Infect Dis 1986;154:579–589.
6.Anaissie, E, Samonis, G, Kontoyiannis, D, et al. Role of catheter colonization and infrequent hematogenous seeding in catheter-related infections. Eur J Clin Microbiol 1995;14:134–137.
7.Safdar, N, Maki, DG. The pathogenesis of catheter-related bloodstream infection with noncuffed short-term central venous catheters. Intensive Care Med 2004;30:62–67.
8.Weightman, NC, Simpson, EM, Speller, DC, Mott, MG, Oakhill, A. Bacteraemia related to indwelling central venous catheters: prevention, diagnosis and treatment. Eur J Clin Microbiol 1988;7:125–129.
9.Pronovost, P, Needham, D, Berenholtz, S, et al. An intervention to decrease catheter-related bloodstream infections in the ICU. New Eng J Med 2006;355:2725–2732.
10.O'Grady, NP, Alexander, M, Burns, LA, et al. Guidelines for the prevention of intravascular catheter-related infections. Clin Infect Dis 2011;52:e162–e193.
11.Maragakis, LL, Bradley, KL, Song, X, et al. Increased catheter-related bloodstream infection rates after the introduction of a new mechanical valve intravenous access port. Infect Control Hosp Epidemiol 2006;27:67–70.
12.Field, K, McFarlane, C, Cheng, AC, et al. Incidence of catheter-related bloodstream infection among patients with a needleless, mechanical valve-based intravenous connector in an Australian hematology-oncology unit. Infect Control Hosp Epidemiol 2007;28:610–613.
13.Salgado, CD, Chinnes, L, Paczesny, TH, Cantey, JR. Increased rate of catheter-related bloodstream infection associated with use of a needleless mechanical valve device at a long-term acute care hospital. Infect Control Hosp Epidemiol 2007;28:684–688.
14.Rupp, ME, Sholtz, LA, Jourdan, DR, et al. Outbreak of bloodstream infection temporally associated with the use of an intravascular needleless valve. Clin Infect Dis 2007;44:1408–1414.
15.Liau, SY, Read, DC, Pugh, WJ, Furr, JR, Russell, AD. Interaction of silver nitrate with readily identifiable groups: relationship to the antibacterial action of silver ions. Letters Appl Microbiol 1997;25:279–283.
16.Maillard, JY, Hartemann, P. Silver as an antimicrobial: facts and gaps in knowledge. Critical Rev Microbiol 2013;39:373–383.
17.Saint, S, Elmore, JG, Sullivan, SD, Emerson, SS, Koepsell, TD. The efficacy of silver alloy-coated urinary catheters in preventing urinary tract infection: a meta-analysis. Am J Med. 1998;105:236–241.
18.Casey, AL, Mermel, LA, Nightingale, P, Elliott, TSJ. Antimicrobial central venous catheters in adults: a systematic review and meta-analysis. Lancet Infect Dis 2008;8:763–776.
19.Maki, DG. In vitro studies of a novel antimicrobial luer-activated needleless connector for prevention of catheter-related bloodstream infection. Clin Infect Dis 2010;50:1580–1587.
20.Edmiston, CE Jr, Markina, V. Reducing the risk of infection in vascular access patients: an in vitro evaluation of an antimicrobial silver nanotechnology luer activated device. Am J Infect Control 2010;38:421–423.
22.Chernetsky Tejedor, S, Garrett, G, Jacob, JT, et al. Electronic documentation of central venous catheter-days: validation is essential. Infect Control Hosp Epidemiol 2013;34:900–907.
23.Fraser, TG, Gordon, SM. CLABSI rates in immunocompromised patients: a valuable patient centered outcome? Clin Infect Dis 2011;52:1446–1450.
24.Sexton, DJ, Chen, LF, Anderson, DJ. Current definitions of central line-associated bloodstream infection: is the emperor wearing clothes? Infect Control Hosp Epidemiol 2010;31:1286–1289.
25.Steinberg, JP, Robichaux, C, Tejedor, SC, Reyes, MD, Jacob, JT. Distribution of pathogens in central line-associated bloodstream infections among patients with and without neutropenia following chemotherapy: evidence for a proposed modification to the current surveillance definition. Infect Control Hosp Epidemiol 2013;34:171–175.
26.Worth, LJ, Slavin, MA, Brown, GV, Black, J. Catheter-related bloodstream infections in hematology: time for standardized surveillance? Cancer 2007;109:1215–1226.
27.See, I, Iwamoto, M, Allen-Bridson, K, Horan, T, Magill, SS, Thompson, ND. Mucosal barrier injury laboratory-confirmed bloodstream infection: results from a field test of a new National Healthcare Safety Network definition. Infect Control Hosp Epidemiol 2013;34:769–776.
28.Bailar, JC, Ederer, F. Significance factors for the ratio of a Poisson variable to its expectation. Biometrics 1964;20:639–643.
29.Brownlee, KA. Statistical theory and methodology in science and engineering. New York: Wiley; 1960.
30.Rosner, B. Fundamentals of biostatistics, 5th ed.Pacific Grove, CA: Duxbury, 1999.
31.Marschall, J, Leone, C, Jones, M, Nihill, D, Fraser, VJ, Warren, DK. Catheter-associated bloodstream infections in general medical patients outside the intensive care unit: a surveillance study. Infect Control Hosp Epidemiol 2007;28:905–909.
32.Casey, AL, Karpanen, TJ, Nightingale, P, Cook, M, Elliott, TSJ. Microbiological comparison of a silver-coated and a non-coated needleless intravascular connector in clinical use. J Hosp Infect 2012;80:299–303.
33.Perez, E, Williams, M, Jacob, JT, et al. Microbial biofilms on needleless connectors for central venous catheters: comparison of standard and silver-coated devices collected from patients in an acute care hospital. J Clin Microbiol 2014;52:823–831.
34.Climo, M, Diekema, D, Warren, DK, et al. Prevalence of the use of central venous access devices within and outside of the intensive care unit: results of a survey among hospitals in the prevention epicenter program of the Centers for Disease Control and Prevention. Infect Control Hosp Epidemiol 2003;24:942–945.
35.Simmons, S, Bryson, C, Porter, S. “Scrub the hub”: cleaning duration and reduction in bacterial load on central venous catheters. Critical Care Nurs Q 2011;34:31–35.
36.Mermel, LA. What is the predominant source of intravascular catheter infections? Clin Infect Dis 2011;52:211–212.