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Comparing Quantitative Culture of a Blood Sample Obtained through the Catheter with Differential Time to Positivity in Establishing a Diagnosis of Catheter-Related Bloodstream Infection

  • Iba Al Wohoush (a1), Javier Cairo (a1), Gopikishan Rangaraj (a1), Bruno Granwehr (a1), Ray Hachem (a1) and Issam Raad (a1)...


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Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1460, Houston, TX 77030 (


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1.Raad, I, Hanna, H, Maki, D. Intravascular catheter-related infections: advances in diagnosis, prevention, and management. Lancet Infect Dis 2007;7:645657.
2.Hanna, R, Raad, II. Diagnosis of catheter-related bloodstream infections. Curr Infect Dis Rep 2005;7:413419.
3.Mermel, LA, Allon, M, Bouza, E, et al.Clinical practice guidelines for the diagnosis and management of intravascular catheter-related infection [published corrections appear in Clin Infect Dis 2010;50(3):457 and 50(7):1079]. Clin Infect Dis 2009;49:115.
4.Safdar, N, Fine, JP, Maki, DG. Methods for diagnosing intravascular device-related bloodstream infection. Ann Intern Med 2005;142:451466.
5.Blot, F, Schmidt, E, Nitenberg, G, et al.Earlier positivity of central venous versus peripheral-blood cultures is highly predictive of catheter-related sepsis. J Clin Microbiol 1998;36:105109.
6.Raad, I, Hanna, HA, Alakech, B, Chatzinikolaou, I, Johnson, MM, Tarrand, J. Differential time to positivity: a useful method for diagnosing catheter-related bloodstream infections. Ann Intern Med 2004;140:1825.
7.DeLong, ER, DeLong, DM, Clarke-Pearson, DL. Comparing the areas under two or more correlated receiver operating characteristic curves: a non-parametric approach. Biometrics 1988;44:837845.
8.Desjardin, JA, Falagas, ME, Ruthazer, R, et al.Clinical utility of blood cultures drawn from indwelling central venous catheters in hospitalized patients with cancer. Ann Intern Med 1999;131:641647.
9.Flynn, PM, Shenep, JL, Barrett, FF. Differential quantitation with commercial blood culture tube for diagnosis of catheter-related infection. J Clin Microbiol 1988;26:10451046.


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