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Colonization With Pseudomonas aeruginosa in Patients Developing Ventilator-Associated Pneumonia

Published online by Cambridge University Press:  31 March 2016

Dennis C.J.J. Bergmans ,
Marc J.M. Bonten ,
Ellen E. Stobberingh ,
Frank H. van Tiel ,
Siebe van der Geest ,
Peter W. de Leeuw  and
Carlo A. Gaillard
Dennis C.J.J. Bergmans*
Affiliation:
Departments of Internal Medicine, University Hospital Maastricht, Maastricht
Marc J.M. Bonten
Affiliation:
Departments of Internal Medicine, University Hospital Maastricht, Maastricht
Ellen E. Stobberingh
Affiliation:
Medical Microbiology, University Hospital Maastricht, Maastricht
Frank H. van Tiel
Affiliation:
Medical Microbiology, University Hospital Maastricht, Maastricht
Siebe van der Geest
Affiliation:
Departments of Internal Medicine, University Hospital Maastricht, Maastricht
Peter W. de Leeuw
Affiliation:
Departments of Internal Medicine, University Hospital Maastricht, Maastricht
Carlo A. Gaillard
Affiliation:
Department of Internal Medicine, Eemland Hospital, Amersfoort, The Netherlands
*
Department of Internal Medicine, University Hospital Maastricht, P Debyelaan 25, PO Box 5800, 6202 AZ Maastricht, The Netherlands
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Abstract

To determine routes of colonization and genotypic variation of Pseudomonas aeruginosa leading to ventilator-associated pneumonia, colonization of the rectum, stomach, oropharynx, and trachea was studied chronologically in 10 patients. Ninety-one isolates of P aeruginosa were genotyped; seven different genotypes were identified. Patients developing ventilator-associated pneumonia caused by P aeruginosa were colonized at multiple body sites and may be colonized with multiple genotypes. The upper respiratory tract is the predominant initial site of colonization with P aeruginosa (Infect Control Hosp Epidemiol 1998;19:853-855).

Type
Concise Communications
Information
Infection Control & Hospital Epidemiology , Volume 19 , Issue 11 , November 1998 , pp. 853 - 856
Copyright
Copyright © The Society for Healthcare Epidemiology of America 1998

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References

1. Bonten, MJM, Gaillard, CA, van der Geest, S, van Tiel, FH, Beysens, A, Smeets, HGW, et al. The role of intragastric acidity and stress ulcer prophylaxis on colonization and infection in mechanically ventilated patients. A stratified, randomized, double blind study of sucralfate versus antacids. Am J Respir Crit Care Med 1995;152:1825–1834.CrossRefGoogle ScholarPubMed
2. Grothues, D, Koopmann, U, Hardt, H, Tümmler, B. Genome fingerprinting of Pseudomonas aeruginosa indicates colonization of cystic fibrosis siblings with closely related strains. J Clin Microbiol 1988;26:1973–1977.CrossRefGoogle ScholarPubMed
3. Tenover, FC, Arbeit, RD, Goering, RV, Mickelsen, PA, Murray, BE, Pershing, DH, et al. Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typing. J Clin Microbiol 1995;33:2233–2239.CrossRefGoogle ScholarPubMed
4. Bergmans, DCJJ, Bonten, MJM, Gaillard, CA, van Tiel, FH, London, NHHJ, van der Geest, S, et al. Value of phenotyping methods as an initial screening of Pseudomonas aeruginosa in epidemiologic studies. Infection 1997;25:350–354.CrossRefGoogle ScholarPubMed
5. Bonten, MJM, Bergmans, DCJJ, Ambergen, AW, de Leeuw, PW, van der Geest, S, Stobberingh, EE, et al. Risk factors for pneumonia, and colonization of respiratory tract and stomach in mechanically ventilated ICU patients. Am J Respir Crit Care Med 1996;154:1339–1346.CrossRefGoogle ScholarPubMed
6. Noone, MR, Pitt, TL, Bedder, M, Hewlett, AM, Rogers, KB. Pseudomonas aeruginosa colonisation in an intensive therapy unit: role of cross infection and host factors. BMJ 1983;286:341–344.CrossRefGoogle Scholar
7. Widmer, AF, Wenzel, RP, Trilla, A, Bale, MJ, Jones, RN, Doebbeling, BN. Outbreak of Pseudomonas aeruginosa infections in a surgical intensive care unit: probable transmission via hands of a health care worker. Clin Infect Dis 1993;16:372–376.CrossRefGoogle Scholar
8. Bonten, MJM, Gaillard, CA, de Leeuw, PW, Stobberingh, EE. Role of colonization of the upper intestinal tract in the pathogenesis of ventilator-associated pneumonia. Clin Infect Dis 1997;24:309–319.CrossRefGoogle ScholarPubMed
9. Niederman, MS, Craven, DE. Editorial response: devising strategies for preventing nosocomial pneumonia—should we ignore the stomach? Clin Infect Dis 1997;24:320–323.CrossRefGoogle Scholar
10. Kropec, A, Huebner, J, Riffel, M, Bayer, U, Benzing, A, Geiger, K, et al. Exogenous or endogenous reservoirs of nosocomial Pseudomonas aeruginosa and Staphylococcus aureus infections in a surgical intensive care unit. Intensive Care Med 1993;19:161–165.CrossRefGoogle ScholarPubMed
11. Murthy, SK, Baltch, AL, Smith, RP, Desjardin, EK, Hammer, MC, Conroy, JV, et al. Oropharyngeal and fecal carriage of Pseudomonas aeruginosa in hospital patients. J Clin Microbiol 1989;27:35–40.CrossRefGoogle ScholarPubMed