Skip to main content Accessibility help

Colonization with Extended-Spectrum β-Lactamase-Producing Escherichia coli and Klebsiella Species in Long-Term Care Facility Residents

  • Ebbing Lautenbach (a1) (a2) (a3) (a4), Jennifer Han (a1), Evelyn Santana (a4), Pam Tolomeo (a3), Warren B. Bilker (a2) (a3) and Joel Maslow (a1) (a4)...


We describe the prevalence of and risk factors for colonization with extended-spectrum (3-lactamase-producing Enterobacteriaceae (ESBL-EB) in the long-term care facility (LTCF) setting. Colonization prevalence differed significantly across the 3 LTCFs evaluated in the study, with recent use of levofloxacin and fecal incontinence demonstrating borderline significant associations with ESBL-EB colonization.

Infect Control Hosp Epidemiol 2012;33(3):302-304


Corresponding author

Division of Infectious Diseases, Department of Medicine, Hospital of the University of Pennsylvania, 3400 Spruce Street, 3rd Floor, Silverstein Building, Suite E, Philadelphia, PA 19104 (


Hide All
1. Schwaber, MJ, Navon-Venezia, S, Kaye, KS, Ben-Ami, R, Schwartz, D, Carmeli, Y. Clinical and economic impact of bacteremia with extended-spectrum-β-lactamase-producing Enterobacteriaceae. Antimicrob Agents Chemother 2006;50:12571262.
2. Pena, C, Pujol, M, Ricart, A, et al. Risk factors for faecal carriage of Klebsiella pneumoniae producing extended spectrum β-lactamase (ESBL-KP) in the intensive care unit. J Hosp Infect 1997;35:916.
3. Du, B, Long, Y, Liu, H, et al. Extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae bloodstream infection: risk factors and clinical outcome. Intensive Care Med 2002;28:17181723.
4. O'Fallon, E, Kandel, R, Schreiber, R, D'Agata, EM. Acquisition of multidrug-resistant gram-negative bacteria: incidence and risk factors within a long-term care population. Infect Control Hosp Epidemiol 2010;31:11481153.
5. Clinical and Laboratory Standards Institute (CLSI). Performance Standards for Antimicrobial Susceptibility Testing. Wayne, PA: CLSI, 2010. CLSI document M100-S20.
6. Tenover, FC, Arbeit, RD, Goering, RV, et al. Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typing. J Clin Microbiol 1995;33:22332239.
7. Mendelson, G, Hait, V, Ben-Israel, J, Gronich, D, Granot, E, Raz, R. Prevalence and risk factors of extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae in an Israeli long-term care facility. Eur J Clin Microbiol Infect Dis 2005;24:1722.
8. Yoo, JS, Byeon, J, Yang, J, Yoo, JI, Chung, GT, Lee, YS. High prevalence of extended-spectrum β-lactamases and plasmid-mediated AmpC β-lactamases in Enterobacteriaceae isolated from long-term care facilities in Korea. Diagn Microbiol Infect Dis 2010;67:261265.
9. March, A, Aschbacher, R, Dhanji, H, et al. Colonization of residents and staff of a long-term-care facility and adjacent acute-care hospital geriatric unit by multiresistant bacteria. Clin Microbiol Infect 2010;16:934944.
10. Rooney, PJ, O'Leary, MC, Loughrey, AC, et al. Nursing homes as a reservoir of extended-spectrum β-lactamase (ESBL)-producing ciprofloxacin-resistant Escherichia coli . J Antimicrob Chemother 2009;64:635641.


Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed