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A Clinical Prediction Rule for Fluoroquinolone Resistance in Healthcare-Acquired Gram-Negative Urinary Tract Infection

  • Pinyo Rattanaumpawan (a1), Pam Tolomeo (a1), Warren B. Bilker (a1) (a2) (a3) and Ebbing Lautenbach (a1) (a2) (a3) (a4)

Abstract

Data from a case-control study were used to derive and internally validate a prediction rule for identifying fluoroquinolone resistance in healthcare-acquired gram-negative urinary tract infection. This prediction rule has an excellent sensitivity and specificity (C-statistic, 0.816). External validation is necessary before implementing this rule to optimize empirical antibiotic use in clinical practice.

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Corresponding author

University of Pennsylvania School of Medicine, Center for Clinical Epidemiology and Biostatistics, 825 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104-6021 (ebbing@mail.med.upenn.edu)

References

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