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Clinical Microbiology Costs for Methods of Active Surveillance for Klebsiella pneumoniae Carbapenemase–Producing Enterobacteriaceae

Published online by Cambridge University Press:  10 May 2016

Amy J. Mathers ,
Melinda Poulter ,
Dawn Dirks ,
Joanne Carroll ,
Costi D. Sifri  and
Kevin C. Hazen
Amy J. Mathers*
Affiliation:
Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia Health System, Charlottesville, Virginia Department of Pathology, University of Virginia Health System, Charlottesville, Virginia
Melinda Poulter
Affiliation:
Department of Pathology, University of Virginia Health System, Charlottesville, Virginia
Dawn Dirks
Affiliation:
Department of Pathology, University of Virginia Health System, Charlottesville, Virginia
Joanne Carroll
Affiliation:
Department of Pathology, University of Virginia Health System, Charlottesville, Virginia
Costi D. Sifri
Affiliation:
Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia Health System, Charlottesville, Virginia
Kevin C. Hazen
Affiliation:
Department of Pathology, University of Virginia Health System, Charlottesville, Virginia
*
Division of Infectious Diseases and International Health, University of Virginia Health System, PO Box 801361, Charlottesville, VA 22908 (ajm5b@virginia.edu)
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Abstract

Objective.

To compare direct laboratory costs of different methods for perirectal screening for carbapenemase-producing Enterobacteriaceae (CPE) colonization.

Design.

Cost-benefit analysis.

Setting.

A university hospital and affiliated long-term acute care hospital (LTACH).

Participants.

Inpatients from the hospital or LTACH.

Methods.

Perirectal samples were collected from inpatients at risk for exposure to CPE. In 2009, we compared the accuracy of the Centers for Disease Control and Prevention (CDC)-recommended CPE screening method with similar methods incorporating a chromogenic agar (CA). We then performed a cost projection analysis using 2012 screening results for the CA method, the CDC method, and a molecular assay with wholesale pricing based on the 2009 analysis. Comparisons of turnaround and personnel time were also performed.

Results.

A total of 185 (2.7%) of 6,860 samples were confirmed as CPE positive during 2012. We previously found that the CDC protocol had a lower sensitivity than the CA method and predicted that the CDC protocol would have missed 92 of the CPE-positive screening results, whereas the modified protocol using CA would have missed 26, assuming similar prevalence and performance. Turnaround time was 3 days using the CDC and CA-modified protocols compared with 1 day for molecular testing. The estimated annual total program cost and total technologist's hours would be the following: CA-modified protocol, $37,441 and 376 hours; CDC protocol, $22,818 and 482 hours; and molecular testing, $224,596 and 343 hours.

Conclusions.

The CDC screening protocol appeared to be the least expensive perirectal screening method. However, expense must be weighed against a lower sensitivity and extra labor needed for additional work-up of non-CPE isolates. The molecular test has the shortest turnaround time but the greatest expense.

Type
Original Article
Information
Infection Control & Hospital Epidemiology , Volume 35 , Issue 4: Special Topic Issue: Carbapenem-Resistant Enterobacteriaceae and Multidrug-Resistant Organisms , April 2014 , pp. 350 - 355
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2014

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Footnotes

a.

Clinical Microbiology Laboratory, Department of Pathology, Duke University Health System, Durham, North Carolina.

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