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Clearance Rate of Carbapenemase-Producing Enterobacteriaceae Carriage Among Hospitalized Patients

  • Kyu-Ri Kim (a1), Jeong-Young Lee (a1), Hee-Youn Park (a1), Sun-Hee Kwak (a1), Young-Ju Lim (a1), Min-Jee Hong (a1), Sun-Kyung Kim (a1), So-Yeon Park (a1), Hyeon-Jeong Kim (a1), Hye-Suk Choi (a1), Mi-Na Kim (a1) (a2), Hye-Ran Choi (a3), Jae-Sim Jeong (a4) and Sang-Ho Choi (a1) (a5)...


During the past decade, carbapenemase-producing Enterobacteriaceae (CPE) has emerged and spread across the world. 1 The major carbapenemase enzymes currently being reported are KPC, NDM-1, VIM, IMP, and OXA. 2 Because carbapenemase can be effectively transmitted via mobile genetic elements, and current therapeutic options for CPE infections are extremely limited, CPE may be one of the most serious contemporary threats to public health. However, very little is known about the characteristics of CPE carriage during hospitalization. The aims of this study were to investigate the clearance rate of CPE carriage and determine the number of consecutive negative cultures required to confirm CPE clearance. We also examined CPE transmission among hospitalized patients.

Infect. Control Hosp. Epidemiol. 2015;36(11):1361–1362


Corresponding author

Address correspondence to Sang-Ho Choi, MD, PhD, 88 Olympic-Ro 43-Gil, Songpa-Gu, Seoul, 138-736, Republic of Korea (


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K.-R.K. and J.-Y.L. contributed equally to this article

Presented in part: Society for Healthcare Epidemiology of America (SHEA) Spring 2015 Conference; Orlando, Florida; May 15, 2015 (Abstract 7102).



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2. Nordmann, P, Poirel, L. The difficult-to-control spread of carbapenemase producers among Enterobacteriaceae worldwide. Clin Microbiol Infect 2014;20:821830.
3. Dortet, L, Brechard, L, Cuzon, G, Poirel, L, Nordmann, P. Strategy for rapid detection of carbapenemase-producing Enterobacteriaceae. Antimicrob Agents Chemother 2014;58:24412445.
4. Lewis, JD, Enfield, KB, Mathers, AJ, Giannetta, ET, Sifri, CD. The limits of serial surveillance cultures in predicting clearance of colonization with carbapenemase-producing Enterobacteriaceae. Infect Control Hospital Epidemiol 36:835837.


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