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A Chryseobacterium meningosepticum Outbreak in a Neonatal Ward

  • Serdal Güngör (a1), Metehan Özen (a1), Aysehan Akinci (a2) and Riza Durmaz (a3)



To report epidemiologic, bacteriologic, and clinical features of a Chryseobacterium meningosepticum outbreak.


Outbreak investigation.


A neonatal intensive care unit (NICU) of a referral teaching hospital.


During 2 weeks in September 2001, four neonates in the NICU developed sepsis and underwent laboratory investigation. Multiple samples were obtained for cultures from endotracheal tubes, mechanical ventilators and humidifier boxes, infant incubators, parenteral and antiseptic solutions, feeding bottles, sinks, faucets, doors, and healthcare workers.


C. meningosepticum was isolated from the blood cultures of four patients. The first isolate was identified 5 days after the death of the index case. Although all isolates were ciprofloxacin susceptible in vitro, the remaining three patients did not respond to ciprofloxacin therapy given for 6 or 7 days. Therapy was switched to vancomycin and rifampin and all three patients survived, with one having a complication (hydrocephalus). Environmental surveillance revealed C. meningosepticum in the stock lipid solution as the source of the epidemic. The outbreak was controlled after discontinuation of intravenous lipid solution, restriction of further neonatal admissions, and thorough disinfection of the unit and its equipment.


Early identification of an epidemic and its source is important in avoiding morbidity and mortality. A contaminated lipid stock bottle was the source of this outbreak associated with multiple cases and one death.


Corresponding author

Uran Kent, E-2 Blok, Daire: 26, Demetevler, Ankara, Turkey


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1.Steinberg, JP, Del Rio, C. Other gram-negative bacilli. In: Mandel, GL, Bennet, JE, Dolin, R, eds. Principles and Practice of Infectious Diseases, 5th ed. Edinburgh: Churchill Livingstone; 2000:24592474.
2.Von Graevenitz, A. Ecology, clinical significance and antimicrobial susceptibility of infrequently encountered glucose-nonfermenting gram-negative rods. In: Gilardi, GL, ed. Laboratory Identification and Clinical Aspects. New York: Marcel Dekker; 1985:181232.
3.The Enterobacteriaceae. In: Koneman, EW, Allen, SD, Vanda, WM, Schreckenberger, PC, Winn, WC, eds. Color Atlas and Textbook of Diagnostic Microbiology, 4th ed. Philadelphia: J. B. Lippincott; 1992:185242.
4.Bloch, KC, Nadarafah, R, Jacobs, R. Chryseobacterium meningosepticum: an emerging pathogen among immunocompromised adults. Medicine 1997;76:3041.
5.Schreckenberger, PC, Graevenitz, A. Non-fermentative gram-negative rods. In: Murray, PR, Baron, EJ, Pfaller, MA, Tenover, FC, Yolken, RH, eds. Manual of Clinical Microbiology, 7th ed. Washington, DC: American Society for Microbiology; 1999:552555.
6.National Committee for Clinical Laboratory Standards. Performance Standards for Antimicrobial Disk Susceptibility Tests, 6th ed. Wayne, PA: National Committee for Clinical Laboratory Standards; 1997. Approved standard M2-A6.
7.Amit, Y, Peleg, O, Singer, R, Arad, ID. Intravenous immunoglobulin for Flavobacterium-induced thrombocytopenia in a premature infant. Am J Perinatal 1991;8:161163.
8.Gardner, P, Griffin, WB, Swartz, MN, Kunz, LJ. Nonfermentative gramnegative bacilli of nosocomial interest. Am J Med 1970;48:735749.
9.Abrahamsen, TG, Finne, PH, Lingoas, E. C. meningosepticum infections in a neonatal intensive care unit. Acta Pediatr Scand 1989;78:5155.
10.Thong, MC, Puthucheary, SD, Lee, E. C. meningosepticum infection: an epidemiological study in a newborn nursery. J Clin Pathol 1981;34:429433.
11.Hogue, SN, Graham, J, Kaufmann, ME, Tabagchali, S. Chryseobacterium meningosepticum outbreak associated with colonization of water taps in a neonatal intensive care unit. J Hosp Infect 2001;47:188192.
12.Hazuka, BT, Dafoni, AS, Talbot, K, Keen, BM. Two outbreaks of C. meningosepticum type E in a neonatal intensive care unit. J Clin Microbiol 1997;6:450455.
13.Bruun, B, Tversrupjensen, E, Lundstrom, K, Andersen, GE. C. meningosepticum infection in a neonatal ward. Eur J Clin Microbiol Infect Dis 1989;816:509514.
14.Dooley, JR, Nims, LJ, Lipp, VH, Beard, A, Delaney, LT. Meningitis of infants caused by C. meningosepticum: report of a patient and analysis of 63 infections. J Trop Pediatr 1980;26:2430.
15.Muder, RR, Brennen, C, Goetz, AM, Wagener, MM. Association with prior fluoroquinolone therapy of widespread ciprofloxacin resistance among gram-negative isolates in a Veterans Affairs medical center. Antimicrob Agents Chemother 1991;35:256258.
16.Horington, SP, Perlino, CA. C. meningosepticum sepsis: disease due to bacteria with unusual antibiotic susceptibility. South Med J 1981;74:764766.
17.Johny, M, Khufdash, FA, Elhag, KM. Antimicrobial treatment of C. meningosepticum infection. Ann Trop Paediatr 1983;3:125128.
18.Di Pentima, MC, Mason, EO Jr, Kaplan, SL. In vitro antibiotic synergy against Flavobacterium meningosepticum: implications for therapeutic options. Clin Infect Dis 1998;26:11691176.
19.Tizer, KB, Cervia, JS, Dunn, AM, Stavola, JJ, Noel, GJ. Successful combination vancomycin and rifampin therapy in a newborn with community acquired C. meningosepticum neonatal meningitis. Pediatr Infect Dis J 1995;14:916917.
20.Ratner, H. C. meningosepticum. Infect Control 1984;5:237239.
21.Lee, EL, Robinson, MJ, Thong, ML, Puthucheary, SD. Rifamycin in neonatal flavobacteria meningitis. Arch Dis Child 1976;51:209213.

A Chryseobacterium meningosepticum Outbreak in a Neonatal Ward

  • Serdal Güngör (a1), Metehan Özen (a1), Aysehan Akinci (a2) and Riza Durmaz (a3)


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