Hostname: page-component-76fb5796d-25wd4 Total loading time: 0 Render date: 2024-04-25T09:25:11.163Z Has data issue: false hasContentIssue false

Characteristics of Bacteremia in Pediatric Oncology Patients Based on Pathogen Classification as Associated with the Gastrointestinal Mucosa or Skin

Published online by Cambridge University Press:  16 March 2015

Aron Flagg
Affiliation:
Center for Pediatric Infectious Diseases, Cleveland Clinic, Cleveland, Ohio Department of Pediatric Hematology/Oncology, Cleveland Clinic, Cleveland, Ohio
Sarah Worley
Affiliation:
Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio.
Charles B. Foster*
Affiliation:
Center for Pediatric Infectious Diseases, Cleveland Clinic, Cleveland, Ohio
*
Address all correspondence to Charles B. Foster, MD, 9500 Euclid Avenue, Desk S-25, Cleveland Clinic, Cleveland, OH 44195 (fosterc3@ccf.org).

Abstract

Factors favoring blood stream infections associated with gastrointestinal mucosa versus skin organisms were explored. An observed difference was attributable to bacteremia from oral flora in patients with acute myelogenous leukemia or mucositis. Our data do not support the conclusion that isolation of enteric Gram-negatives is unrelated to the central catheter.

Infect Control Hosp Epidemiol 2015;00(0): 1–4

Type
Concise Communications
Copyright
© 2015 by The Society for Healthcare Epidemiology of America. All rights reserved 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1. CDC/NHSN Surveillance definition of healthcare-associated infection and criteria for specific types of infections in the acute care setting. Centers for Disease Control and Prevention website. http://www.cdc.gov/nhsn/PDFs/pscManual/17pscNosInfDef_current.pdf. Published 2015. Accessed February 23, 2015.Google Scholar
2. Tancrede, CH, Andremont, AO. Bacterial translocation and Gram-negative bacteremia in patients with hematological malignancies. J Infect Dis 1985;152:99103.Google Scholar
3. Taur, Y, Pamer, EG. The intestinal microbiota and susceptibility to infection in immunocompromised patients. Curr Opin Infect Dis 2013;26:332337.Google Scholar
4. Rossetti, F, Cesaro, S, Putti, MC, Zanesco, L. High-dose cytosine arabinoside and viridans streptococcus sepsis in children with leukemia. Pediatr Hematol Oncol 1995;12:387392.Google Scholar
5. Burden, AD, Oppenheim, BA, Crowther, D, et al. Viridans streptococcal bacteraemia in patients with haematological and solid malignancies. Eur J Cancer 1991;27:409411.Google Scholar
6. Fraser, TG, Gordon, SM. CLABSI rates in immunocompromised patients: a valuable patient centered outcome? Clin Infect Dis 2011;52:14461450.Google Scholar
7. See, I, Iwamoto, M, Allen-Bridson, K, Horan, T, Magill, SS, Thompson, ND. Mucosal barrier injury laboratory-confirmed bloodstream infection: results from a field test of a new National Healthcare Safety Network definition. Infect Control Hosp Epidemiol 2013;34:769776.CrossRefGoogle ScholarPubMed
8. Fong, KS, Banks, M, Benish, R, et al. Intensity of vascular catheter use in critical care: impact on catheter-associated bloodstream infection rates and association with severity of illness. Infect Control Hosp Epidemiol 2012;33:12681270.Google Scholar
9. Rinke, ML, Bundy, DG, Chen, AR, et al. Central line maintenance bundles and CLABSIs in ambulatory oncology patients. Pediatrics 2013;132:e1403e1412.CrossRefGoogle ScholarPubMed
10. Rinke, ML, Chen, AR, Bundy, DG, et al. Implementation of a central line maintenance care bundle in hospitalized pediatric oncology patients. Pediatrics 2012;130:e996e1004.Google Scholar