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An Outbreak of Extended-Spectrum β-Lactamase–Producing Klebsiella pneumoniae in a Neonatal Intensive Care Unit

  • Pranita D. Tamma (a1), Patrice Savard (a2), Tibor Pál (a3), Ágnes Sonnevend (a3), Trish M. Perl (a4) and Aaron M. Milstone (a1)...


We present a large outbreak of ESBL-producing Klebsiella pneumoniae in a neonatal intensive care unit that resulted in 31 colonized infants, 10 invasive infections, and 5 attributable deaths over a 5-month period. Although the source of infection was unknown, overcrowding and understaffing appeared to have been aggravating factors.


Corresponding author

Pranita D. Tamma, MD, Johns Hopkins Medical Institutions, Division of Pediatric Infectious Diseases, 200 North Wolfe Street, Suite 3155, Baltimore, MD 21287 (


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