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Achieving and Sustaining Ventilator-Associated Pneumonia–Free Time among Intensive Care Units (ICUs): Evidence from the Keystone ICU Quality Improvement Collaborative

  • Dany S. Matar (a1), Julius C. Pham (a2) (a3), Thomas A. Louis (a4) and Sean M. Berenholtz (a2) (a5) (a6)


Our retrospective analysis of the Michigan Keystone intensive care unit (ICU) collaborative demonstrated that adult ICUs could achieve and sustain a zero rate of ventilator-associated pneumonia (VAP) for a considerable number of ventilator and calendar months. Moreover, the results highlight the importance of adjustment for ventilator-days before comparing VAP-free time among ICUs.


Corresponding author

Johns Hopkins University, Armstrong Institute for Patient Safety and Quality, 750 E. Pratt Street, 15th Floor, Baltimore, MD 21202 (


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1.Safdar, N, Dezfulian, C, Collard, HR, Saint, S. Clinical and economic consequences of ventilator-associated pneumonia: a systematic review. Crit Care Med 2005;33:21842193.
2.Klompas, M. Prevention of ventilator-associated pneumonia. Expert Rev Anti Infect Ther 2010;8:791800.
3.Pogorzelska, M, Stone, PW, Furuya, EY, et al. Impact of the ventilator bundle on ventilator-associated pneumonia in intensive care unit. Int J Qual Health Care 2011;23:538544.
4.Wip, C, Napolitano, L. Bundles to prevent ventilator-associated pneumonia: how valuable are they? Curr Opin Infect Dis 2009;22:159166.
5.O'Keefe-McCarthy, S, Santiago, C, Lau, G. Ventilator-associated pneumonia bundled strategies: an evidence-based practice. Worldviews Evid Based Nurs 2008;5:193204.
6.Klompas, M. Ventilator-associated pneumonia: is zero possible? Clin Infect Dis 2010;51:11231126.
7.Marra, AR, Cal, RG, Silva, CV, et al. Successful prevention of ventilator-associated pneumonia in an intensive care setting. Am J Infect Control 2009;37:619625.
8.Berenholtz, SM, Pham, JC, Thompson, DA, et al. Collaborative cohort study of an intervention to reduce ventilator-associated pneumonia in the intensive care unit. Infect Control Hosp Epidemiol 2011;32:305314.
9.Horan, TC, Andrus, M, Dudeck, MA. CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. Am J Infect Control 2008;36:309332.
10.Ashraf, M, Ostrosky-Zeichner, L. Ventilator-associated pneumonia: a review. Hosp Pract (Minneap) 2012;40:93105.


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