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Variable duration of viral shedding in cancer patients with coronavirus disease 2019 (COVID-19)

Published online by Cambridge University Press:  27 August 2021

N. Esther Babady
Affiliation:
Microbiology Service, Department of Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York
Bevin Cohen
Affiliation:
Center for Nursing Research and Innovation at The Mount Sinai Hospital, New York, New York
Tara McClure
Affiliation:
Infection Control Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York
Karin Chow
Affiliation:
Infection Control Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York
Mario Caldararo
Affiliation:
Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York
Krupa Jani
Affiliation:
Microbiology Service, Department of Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York
Tracy McMillen
Affiliation:
Microbiology Service, Department of Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York
Ying Taur
Affiliation:
Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York Department of Medicine, Weill Cornell Medical College, New York, New York
Monika Shah
Affiliation:
Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York Department of Medicine, Weill Cornell Medical College, New York, New York
Elizabeth Robilotti
Affiliation:
Infection Control Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York Department of Medicine, Weill Cornell Medical College, New York, New York
Anoshe Aslam
Affiliation:
Infection Control Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York
Mini Kamboj*
Affiliation:
Infection Control Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York Department of Medicine, Weill Cornell Medical College, New York, New York
*
Author for correspondence: Mini Kamboj, E-mail: kambojm@mskcc.org

Abstract

In this retrospective study of 105 severe acute respiratory coronavirus virus 2 (SARS-CoV-2)–infected cancer patients with longitudinal nasopharyngeal sampling, the duration of viral shedding and time to attain cycle threshold >30 was longer in patients with hematologic malignancy than in those with solid tumors. These findings have important public health implications.

Type
Original Article
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of The Society for Healthcare Epidemiology of America

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Footnotes

a

Authors of equal contribution.

References

Richardson, L, Brite, J, Del Castillo, M, et al. Comparison of respiratory virus shedding by conventional and molecular testing methods in patients with haematological malignancy. Clin Microbiol Infect 2016;22:380:e1e7.CrossRefGoogle ScholarPubMed
Aydillo, T, Gonzalez-Reiche, AS, Aslam, S,, et al. Shedding of viable SARS-CoV-2 after immunosuppressive therapy for cancer. N Engl J Med 2020;383:25862588.CrossRefGoogle ScholarPubMed
van Kampen, JJA, van de Vijver, D, Fraaij, PLA, et al. Duration and key determinants of infectious virus shedding in hospitalized patients with coronavirus disease-2019 (COVID-19). Nat Commun 2021;12:267.CrossRefGoogle Scholar
Choi, B, Choudhary, MC, Regan, J, et al. Persistence and evolution of SARS-CoV-2 in an immunocompromised host. N Engl J Med 2020;383:22912293.CrossRefGoogle Scholar
Heinzerling, A, Stuckey, MJ, Scheuer, T, et al. Transmission of COVID-19 to health care personnel during exposures to a hospitalized patient—Solano County, California, February 2020. Morb Mortal Wkly Rep 2020;69:472476.CrossRefGoogle Scholar
Arons, MM, Hatfield, KM, Reddy, SC, et al. Presymptomatic SARS-CoV-2 infections and transmission in a skilled nursing facility. N Engl J Med 2020 ;382:20812090.CrossRefGoogle Scholar
Robilotti, EV, Babady, NE, Mead, PA, et al. Determinants of COVID-19 disease severity in patients with cancer. Nat Med 2020;26:12181223.CrossRefGoogle ScholarPubMed
Bullard, J, Dust, K, Funk, D, et al. Predicting infectious SARS-CoV-2 from diagnostic samples. Clin Infect Dis 2020;71:26632666.CrossRefGoogle ScholarPubMed
La Scola, B, Le Bideau, M, Andreani, J, et al. Viral RNA load as determined by cell culture as a management tool for discharge of SARS-CoV-2 patients from infectious disease wards. Eur J Clin Microbiol Infect Dis 2020;39:10591061.CrossRefGoogle ScholarPubMed
Baang, JH, Smith, C, Mirabelli, C, et al. Prolonged severe acute respiratory syndrome coronavirus 2 replication in an immunocompromised patient. J Infect Dis 2021;223:2327.CrossRefGoogle Scholar
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