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Use of whole-genome sequencing to guide a Clostridioides difficile diagnostic stewardship program

Published online by Cambridge University Press:  15 May 2019

Kunal K. Jakharia
Affiliation:
Department of Internal Medicine, MedStar Washington Hospital Center, Washington, DC
Ghassan Ilaiwy
Affiliation:
Department of Internal Medicine, MedStar Washington Hospital Center, Washington, DC
Siobhan S. Moose
Affiliation:
Departments of Infection Prevention and Infectious Diseases, MedStar Washington Hospital Center, Washington, DC
Masashi Waga
Affiliation:
Department of Pathology and Laboratory Medicine, MedStar Washington Hospital Center, Washington, DC
Lakshmi Appalla
Affiliation:
Multi-Drug Resistant Organism Repository and Surveillance Network (MRSN), Walter Reed Army Institute of Research, Silver Spring, MD
Joel D. McAlduff
Affiliation:
Information Services, MedStar Health, Columbia, Maryland
Lynne V. Karanfil
Affiliation:
Infection Prevention, MedStar Institute for Quality and Safety, Columbia, Maryland
Patrick T. McGann
Affiliation:
Multi-Drug Resistant Organism Repository and Surveillance Network (MRSN), Walter Reed Army Institute of Research, Silver Spring, MD
Glenn W. Wortmann
Affiliation:
Departments of Infection Prevention and Infectious Diseases, MedStar Washington Hospital Center, Washington, DC Infection Prevention, MedStar Institute for Quality and Safety, Columbia, Maryland
Corresponding

Abstract

Whole-genome sequencing (WGS) has yielded new insights into the transmission patterns of healthcare facility-onset Clostridioides difficile infection (HO-CDI). WGS results prompted a focused diagnostic stewardship program, which was associated with a significant and sustained decrease in HO-CDI at large, urban hospital.

Type
Concise Communication
Copyright
© 2019 by The Society for Healthcare Epidemiology of America. All rights reserved

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Footnotes

PREVIOUS PRESENTATION. Preliminary results of this work were presented at the 2018 Infectious Diseases Society of America meeting on October 4, 2018, in San Francisco, California.

References

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