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Serologic Evaluation of MERS Screening Strategy for Healthcare Personnel During a Hospital-Associated Outbreak

Published online by Cambridge University Press:  14 November 2016

Jae-Hoon Ko
Affiliation:
Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, Korea
Ji Yeon Lee
Affiliation:
Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, Korea
Jin Yang Baek
Affiliation:
Asia Pacific Foundation for Infectious Diseases (APFID), Seoul, Korea
Hyeri Seok
Affiliation:
Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, Korea
Ga Eun Park
Affiliation:
Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, Korea
Ji Yong Lee
Affiliation:
Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, Korea
Sun Young Cho
Affiliation:
Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, Korea
Young Eun Ha
Affiliation:
Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, Korea
Cheol-In Kang
Affiliation:
Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, Korea
Ji-Man Kang
Affiliation:
Division of Infectious Diseases, Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Yae-Jean Kim*
Affiliation:
Division of Infectious Diseases, Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Eun-Suk Kang
Affiliation:
Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
So Hyun Kim
Affiliation:
Asia Pacific Foundation for Infectious Diseases (APFID), Seoul, Korea
Ik Joon Jo
Affiliation:
Department of Emergency Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Chi Ryang Chung
Affiliation:
Department of Critical Care Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Myong-Joon Hahn
Affiliation:
Department of Molecular Cell Biology, Center for Molecular Medicine, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon, Korea
Marcel A. Müller
Affiliation:
Institute of Virology, University of Bonn Medical Centre, Bonn, Germany
Christian Drosten
Affiliation:
Institute of Virology, University of Bonn Medical Centre, Bonn, Germany German Center for Infection Research (DZIF)-Partner Site Bonn-Cologne, Bonn, Germany.
Doo Ryeon Chung
Affiliation:
Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, Korea Asia Pacific Foundation for Infectious Diseases (APFID), Seoul, Korea
Jae-Hoon Song
Affiliation:
Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, Korea Asia Pacific Foundation for Infectious Diseases (APFID), Seoul, Korea
Kyong Ran Peck*
Affiliation:
Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, Korea
*
Address correspondence to Kyong Ran Peck, MD, PhD, Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81, Irwon-ro, Gangnam-gu, Seoul 135-710, Korea (krpeck@skku.edu) or to Yae-Jean Kim, MD, PhD, Division of Infectious Diseases, Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81, Irwon-ro, Gangnam-gu, Seoul 135-710, Korea; (yaejeankim@skku.edu).
Address correspondence to Kyong Ran Peck, MD, PhD, Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81, Irwon-ro, Gangnam-gu, Seoul 135-710, Korea (krpeck@skku.edu) or to Yae-Jean Kim, MD, PhD, Division of Infectious Diseases, Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81, Irwon-ro, Gangnam-gu, Seoul 135-710, Korea; (yaejeankim@skku.edu).

Abstract

To evaluate the appropriateness of the screening strategy for healthcare personnel (HCP) during a hospital-associated Middle East Respiratory Syndrome (MERS) outbreak, we performed a serologic investigation in 189 rRT-PCR–negative HCP exposed and assigned to MERS patients. Although 20%–25% of HCP experienced MERS-like symptoms, none of them showed seroconversion by plaque reduction neutralization test (PRNT).

Infect Control Hosp Epidemiol 2017;38:234–238

Type
Concise Communications
Copyright
© 2016 by The Society for Healthcare Epidemiology of America. All rights reserved 

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Footnotes

a

Authors of equal contribution.

b

Corresponding authors of equal contribution.

References

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