Hostname: page-component-8448b6f56d-wq2xx Total loading time: 0 Render date: 2024-04-16T05:42:51.369Z Has data issue: false hasContentIssue false

A Nosocomial Outbreak of Escherichia coli Producing CTX-M-15 and OXA-30 β-Lactamase

Published online by Cambridge University Press:  21 June 2016

Hyunjoo Pai
Affiliation:
Department of Internal Medicine, College of Medicine, Hanyang University, Seoul, Korea
Mi Ran Kim
Affiliation:
Department of Pediatrics, College of Medicine, Hanyang University, Seoul, Korea
Mi-Ran Seo
Affiliation:
Department of Internal Medicine, College of Medicine, Hanyang University, Seoul, Korea
Tae Yeal Choi
Affiliation:
Department of Clinical Microbiology, College of Medicine, Hanyang University, Seoul, Korea
Sung Hee Oh*
Affiliation:
Department of Pediatrics, College of Medicine, Hanyang University, Seoul, Korea
*
Department of Pediatrics, College of Medicine, Hanyang University, 17 Haengdang-dong, Seongdonggu, Seoul 133-791, Korea (sungheeo@hanyang.ac.kr)

Abstract

During a survey of the prevalent subtypes of extended-spectrum β-lactamases in a university hospital in Korea, a nosocomial outbreak of Escherichia coli producing CTX-M-15 and OXA-30 β-lactamases was detected. The outbreak comprised various infections, including bloodstream infections and colonization, and persisted for several months in various areas of the hospital.

Type
Concise Communications
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2006

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1.Bradford, PA. Extended-spectrum β-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat. Clin Microbiol Rev 2001; 14:933951.Google Scholar
2.Bonnet, R. Growing group of extended-spectrum β-lactamases: the CTX-M enzymes. Antimicrob Agents Chemother 2004; 48:114.Google Scholar
3.Kim, J, Kwon, Y, Pai, H, et al. Survey of Klebsiella pneumoniae strains producing extended-spectrum β-lactamases: prevalence of SHV-12 and SHV-2a in Korea. J Clin Microbiol 1998; 36:14461449.CrossRefGoogle ScholarPubMed
4.Kim, YK, Pai, H, Lee, J, et al. Bloodstream infections by extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae in children: epidemiology and clinical outcome. Antimicrob Agents Chemother 2002;46:14811491.CrossRefGoogle ScholarPubMed
5.Pai, H, Kang, CI, Byeon, JH, et al. Epidemiology and clinical features of bloodstream infections caused by AmpC type β-lactamase–producing Klebsiella pneumoniae. Antimicrob Agents Chemother 2004; 48:37203728.Google Scholar
6.Pai, H, Choi, EH, Lee, HJ, et al. Identification of CTX-M-14 extended-spectrum β-lactamase in clinical isolates of Shigella sonnei, Escherichia coli, and Klebsiella pneumoniae in Korea. J Clin Microbiol 2001; 39:37473749.Google Scholar
7.Kim, J, Lim, YM, Jeong, YS, Seol, SY. Occurrence of CTX-M-3, CTX-M-15, CTX-M-14, and CTX-M-9 extended-spectrum β-lactamases in Entero-bacteriaceae clinical isolates in Korea. Antimicrob Agents Chemother 2005; 49:15721575.Google Scholar
8.Kim, J, Lim, YM, Rheem, I, et al. CTX-M and SHV-12 β-lactamases are the most common extended-spectrum enzymes in clinical isolates of Escherichia coli and Klebsiella pneumoniae collected from 3 university hospitals within Korea. FEMS Microbiol Lett 2005; 245:9398.Google Scholar
9.Mathew, A, Harris, AM, Marshall, MJ, Ross, GW. The use of analytical isoelectric focusing for detection and identification of β-lactamases. J Gen Microbiol 1975; 88:169178.CrossRefGoogle ScholarPubMed
10.Pai, H, Lyu, S, Lee, JH, et al. Survey of extended-spectrum β-lactamases in clinical isolates of Escherichia coli and Klebsiella pneumoniae: prevalence of TEM-52 in Korea. J Clin Microbiol 1999; 37:17581763.Google Scholar
11.National Committee for Clinical Laboratory Standards. Approved standard. In: Performance Standards for Antimicrobial Disk Susceptibility Tests. 8th ed. Wayne, PA: National Committee for Clinical Laboratory Standards; 2003. NCCLS document M2-A8.Google Scholar
12.Macrina, FL, Kopecko, DJ, Jones, KR, Ayers, DJ, McCowen, SM. A multiple plasmid–containing Escherichia coli strain: convenient source of size reference plasmid molecules. Plasmid 1978; 1:417420.Google Scholar
13.Kado, CI, Liu, ST. Rapid procedure for detection and isolation of large and small plasmids. J Bacteriol 1981; 145:13651373.Google Scholar
14.Tarkka, E, Ahman, H, Siitonen, A. Ribotyping as an epidemiologic tool for Escherichia coli. Epidemiol Infect 1994; 112:263274.Google Scholar
15.Karim, A, Poirel, L, Nagarajan, S, Nordmann, P. Plasmid-mediated extended-spectrum β-lactamase (CTX-M-3 like) from India and gene association with insertion sequence ISEcp1. FEMS Microbiol Lett 2001; 201:237241.Google ScholarPubMed
16.Boyd, DA, Tyler, S, Christianson, S, et al. Complete nucleotide sequence of a 92-kilobase plasmid harboring the CTX-M-15 extended-spectrum beta-lactamase involved in an outbreak in long-term-care facilities in Toronto, Canada. Antimicrob Agents Chemother 2004; 48:37583764.CrossRefGoogle Scholar
17.Woodford, N, Ward, ME, Kaufmann, ME, et al. Community and hospital spread of Escherichia coli producing CTX-M extended-spectrum β-lactamases in the UK. J Antimicrob Chemother 2004; 54:735743.Google Scholar
18.Dubois, V, Arpin, C, Quentin, C, et al. Decreased-susceptibility to cefepime in a clinical strain of Escherichia coli related to plasmid- and integron-encoded OXA-30 β-lactamase. Antimicrob Agents Chemother 2003; 47:23802381.Google Scholar