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Emergence of Daptomycin-Resistant VRE: Experience of a Single Institution

Published online by Cambridge University Press:  02 January 2015

Mini Kamboj*
Affiliation:
Infectious Disease Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York 10065
Nina Cohen
Affiliation:
Infectious Disease Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York 10065
Kathleen Gilhuley
Affiliation:
Microbiology Service, Department of Clinical Laboratories, Memorial Sloan-Kettering Cancer Center, New York, New York 10065
N. Esther Babady
Affiliation:
Microbiology Service, Department of Clinical Laboratories, Memorial Sloan-Kettering Cancer Center, New York, New York 10065
Susan K. Seo
Affiliation:
Infectious Disease Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York 10065
Kent A. Sepkowitz
Affiliation:
Infectious Disease Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York 10065
*
Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, Box 9, New York, NY 10065 (kambojm@mskcc.org)

Abstract

Recent surveillance from US hospitals shows that more than 99.5% of vancomycin-resistant enterococci (VRE) isolates remain susceptible to daptomycin. This report describes emergence of daptomycin-resistant VRE at a major cancer center. The percentage of patients with daptomycin-resistant VRE bacteremia increased from 3.4% in 2007 to 15.2% in 2009 (P = .03). Without susceptibility data, empiric daptomycin therapy for VRE infections should be used with caution.

Type
Concise Communication
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2011

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