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Characterization of resistance to newer antimicrobials among carbapenem-resistant Klebsiella pneumoniae in the post–acute-care setting

Published online by Cambridge University Press:  28 July 2022

Helen L. Zhang*
Affiliation:
Division of Infectious Diseases, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania
Kyle J. Gontjes
Affiliation:
Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan
Jennifer H. Han
Affiliation:
Division of Infectious Diseases, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine, Pennsylvania
Kevin Alby
Affiliation:
Department of Pathology and Lab Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Zena Lapp
Affiliation:
Department of Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, Michigan
Evan Snitkin
Affiliation:
Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan
Ellie J.C. Goldstein
Affiliation:
R.M. Alden Research Laboratory, Santa Monica, California Department of Medicine, David Geffen School of Medicine at the University of California, Los Angeles, California
Sean Muldoon
Affiliation:
ScionHealth, Louisville, Kentucky
Pam Tolomeo
Affiliation:
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine, Pennsylvania
Ebbing Lautenbach
Affiliation:
Division of Infectious Diseases, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine, Pennsylvania
*
Author for correspondence: Helen L. Zhang, E-mail: helen.zhang1@pennmedicine.upenn.edu. Or Ebbing Lautenbach, E-mail: ebbing@pennmedicine.upenn.edu

Abstract

We assessed susceptibility patterns to newer antimicrobial agents among clinical carbapenem-resistant Klebsiella pneumoniae (CRKP) isolates from patients in long-term acute-care hospitals (LTACHs) from 2014 to 2015. Meropenem-vaborbactam and imipenem-relebactam nonsusceptibility were observed among 9.9% and 9.1% of isolates, respectively. Nonsusceptibility to ceftazidime-avibactam (1.1%) and plazomicin (0.8%) were uncommon.

Type
Concise Communication
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of The Society for Healthcare Epidemiology of America

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