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A t-haplotype (tw75) overlapping two complementation groups

Published online by Cambridge University Press:  14 April 2009

Karen Artzt ,
Bruce Babiarz  and
Dorothea Bennett
Karen Artzt
Affiliation:
Sloan-Kettering Institute for Cancer Research, Laboratory of Developmental Genetics, New York, New York, U.S.A.
Bruce Babiarz
Affiliation:
Sloan-Kettering Institute for Cancer Research, Laboratory of Developmental Genetics, New York, New York, U.S.A.
Dorothea Bennett
Affiliation:
Sloan-Kettering Institute for Cancer Research, Laboratory of Developmental Genetics, New York, New York, U.S.A.
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The recessive lethal T/t-complex haplotype tw75 was isolated from Jena, East Germany, prior to 1973. It was at first thought to be a standard member of the tw5 complementation group because matings of T/tw75 × T/tw5 produced tailless offspring only (Dunn, Bennett & Cookingham, 1973). Cross tests with all other complementation groups and embryological studies have recently been completed, with results demonstrating that tw75 does not complement the members of either the tw5 or the tw1 complementation groups. Histological studies show that compound embryos tw75/tw5 and tw75/tw1 die with symptoms indistinguishable from tw5/tw5 and tw1/tw1 homozygtes respectively. Thus tw75 represents the first confirmed isolation of a t-haplotype that overlaps two complementation groups.

Type
Research Article
Information
Genetics Research , Volume 33 , Issue 3 , June 1979 , pp. 279 - 285
Copyright
Copyright © Cambridge University Press 1979

References

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