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Relative growth of the skull and postcranium in giant transgenic mice

  • Brian T. Shea (a1), Robert E. Hammer (a2), Ralph L. Brinster (a2) and Matthew R. Ravosa (a1)

Summary

Cross-sectional allometric growth patterns of the cranial and postcranial skeleton were compared between giant transgenic (MT-rGH) mice and their normal littermate controls. Body weights, external body dimensions, and a series of cranial and postcranial linear dimensions of the skeleton were determined for samples of known age. Comparative bivariate and multivariate allometric analyses were completed in order to determine whether (1) the larger transgenic mice differed significantly from the normal controls in aspects of body and skeletal proportions, and (2) any such proportion differences resulted from general allometric effects of overall weight or skeletal size increase. Results demonstrate that the transgenic mice do exhibit significantly different body and skeletal proportions than normal control adults. Allometric comparisons of the skeletal dimensions relative to body weight reveal similar coefficients of growth allometry but several differences in y-intercept values in the transgenic vs. control groups. The comparisons among the skeletal dimensions of the skull and postcranium generally reveal the sharing and differential extension of common growth allometries in the two groups. Thus, the elevated levels of growth hormone (GH) and insulin-like growth factor I (IGF-I) in the transgenic mice appear to result in increased overall growth for the various skeletal elements, but in the relative proportions determined by intrinsic growth controls within that system.

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References

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Albrecht, G. H. (1978). The craniofacial morphology of the Sulawesi macaques. Contributions to Primatology 13, 1111.
Atchley, W. R., Rutledge, J. J. & Cowley, D. E. (1981). Genetic components of size and shape. II. Multivariate covariance patterns in the rat and mouse skull. Evolution 35, 10371055.
Atchley, W. R., Rutledge, J. J. & Cowley, D. E. (1982). A multivariate statistical analysis of direct and correlated response to selection in the rat. Evolution 36, 677698.
Bartke, A. (1965). The response of two types of dwarf mice to growth hormone, thyrotropin, and thyroxine. General and Comparative Endocrinology 5, 418426.
Bartke, A. (1979). Genetic models in the study of anterior pituitary hormones. In Genetic Variations in Hormone Systems (ed. Shire, J. G. M.), pp. 113126. Boca Raton, Florida: CRC Press.
Bryant, P. J. & Simpson, P. (1984). Intrinsic and extrinsic control of growth in developing organs. Quarterly Review of Biology 59, 387415.
Butterfield, R. M., Griffiths, D. A., Thompson, J. M., Zamora, J. & James, A. M. (1983). Changes in body composition relative to weight and maturity in large and small strains of Australian Merino rams. I. Muscle, bone and fat. Animal Production 36, 2937.
Eisen, E. J. (1976). Results of growth curve analyses in mice and rats. Journal of Animal Science 42, 10081023.
Eisen, E. J. (1986). Maturing patterns of organ weights in mice selected for rapid postweaning gain. Theoretical and Applied Genetics 73, 148157.
Eisen, E. J. (1987). Effects of selection for rapid postweaning gain on maturing patterns of fat depots in mice. Journal of Animal Science 64, 133147.
Eisen, E. J., Lang, B. J. & Legates, J. E. (1969). Comparison of growth functions within and between lines of mice selected for large and small body weight. Theoretical and Applied Genetics 39, 251260.
Falconer, D. S., Gauld, I. K. & Roberts, R. C. (1978 a). Cell numbers and cell sizes in organs of mice selected for large and small body size. Genetical Research 31, 287301.
Falconer, D. S., Gauld, I. K. & Roberts, R. C. (1978 b). Growth control in chimaeras. In Genetic Mosaics and Chimeras in Mammals (ed. Russell, L. B.), pp. 3949. New York: Plenum Press.
Gould, S. J. (1975). Allometry in primates, with emphasis on scaling and the evolution of brain size. Contributions to Primatology 5, 244292.
Green, C. V. & Fekete, E. (1933). Differential growth in the mouse. Journal of Experimental Zoology 66, 351370.
Hall, B. K. (1983). Epigenetic control in development and evolution. In Development and Evolution (ed. Goodwin, B. C., Holder, N. & Wylie, C. G.), pp. 353378. Cambridge: Cambridge University Press.
Hammer, R. E., Palmiter, R. D. & Brinster, R. L. (1984). The introduction of metallothionein-growth hormone fusion genes into mice. In Advances in Gene Technology: Human Genetic Disorders (ed. Ahmad, F., Black, S., Schultz, J., Scott, W. & Whelan, W. J.), vol. 1, pp. 5255. ICSU Press.
Hammer, R. E., Brinster, R. L. & Palmiter, R. D. (1986). Use of gene transfer to increase animal growth. Cold Spring Harbour Symposia on Quantitative Biology 50, 379.
Hughes, P. C. R. & Tanner, J. M. (1970). A longitudinal study of the growth of the black-hooded rat: methods of measurement and rates of growth for skull, limbs, pelvis, nose-rump and tail lengths. Journal of Anatomy 106, 349370.
Huxley, J. S. (1932). Problems of Relative Growth. London: Methuen.
Jolicoeur, P. (1963). The multivariate generalization of the allometry equation. Biometrics 19, 497499.
Katz, M. J. (1980). Allometry formula: a cellular model. Growth 44, 8996.
Laird, A. K. (1965). Dynamics of relative growth. Growth 29, 249263.
Nielsen, E. L. (1953). Studies on hereditary dwarfism in mice. XIII. Effect of the growth hormone and thyroxin on the growth of bones in mice with hereditary pituitary dwarfism. Acta pathologica et microbiologica Scandinavica 30, 1020.
Palmiter, R. D., Brinster, R. L., Hammer, R. E., Trumbauer, M. E., Rosenfeld, M. G., Birnberg, N. C. & Evans, R. M. (1982). Dramatic growth mice that develop from eggs micro-injected with metallothionein-growth hormone fusion genes. Nature 300, 611615.
Palmiter, R. D., Norstedt, G., Gelinas, R. E., Hammer, R. E. & Brinster, R. L. (1983). Metallothionein-human GH fusion genes stimulate growth of mice. Science 222, 809814.
Pidduck, H. G. & Falconer, D. S. (1978). Growth hormone function in strains of mice selected for large and small size. Genetical Research 32, 195206.
Rutledge, J. J., Eisen, E. J. & Legates, J. E, (1975). Correlated response in skeletal traits and replicate variation in selected lines of mice. Theoretical and Applied Genetics 46, 2631.
Shea, B. T. (1981). Relative growth of the limbs and trunk of African apes. American Journal of Physical Anthropology 56, 179202.
Shea, B. T. (1985). Bivariate and multivariate growth allometry: statistical and biological considerations. Journal of Zoology 206, 367390.
Shea, B. T. (1988). Heterochrony in primates. In Heterochrony in Evolution (ed. McKinney, M. L.), pp. 237266. New York: Plenum Press.
Shea, B. T. (in press). Dynamic morphology: growth, life history and ecology in primate evolution. In Primate Life History Evolution (ed. DeRousseau, J.). New York: Plenum Press.
Shea, B. T. & Pagezy, H. (1988). Allometric analyses of body form in Central African pygmies. American Journal of Physical Anthropology 75, 269270.
Shea, B. T. & Bailey, R. C. (1989). Allometric growth of body proportions in Efe pygmies of Zaire. American Journal of Physical Anthropology 78, 300301.
Shea, B. T. (n.d.). The developmental control of skeletal growth allometries: evidence from giant transgenic (MT-rGH) and dwarf mutant (dw / dw) mice. In preparation.
Shea, B. T., Hammer, R. E. & Brinster, R. L. (1987). Growth allometry of the organs in giant transgenic mice. Endocrinology 121, 17.
Shimizu, H., Yamadate, T., Awata, T., Ueda, J. & Hachinohe, Y. (1985). The effect of selection for increased body weight on the growth of bones in mice. Japanese Journal of Zootechnical Science 56, 318332.
Simpson, M. E., Asling, C. W. & Evans, H. M. (1950). Some endocrine influences on skeletal growth and differentiation. Yale Journal of Biology and Medicine 23, 127.
van Buul-Offers, S. (1983). Hormonal and other inherited growth disturbances in mice with special reference to the Snell dwarf mouse. Acta endocrinologia (Suppl. 258) 103, 147.
van Buul-Offers, S. & van den Brande, J. L. (1978). The Snell dwarf mouse. I. General growth pattern, before and during growth hormone and thyroxine therapy. Acta endocrinologia 89, 632645.
Wilkinson, L. (1988 a). SYSTAT: the System for Statistics. Evanston, IL: SYSTAT, Inc.
Wilkinson, L. (1988 b). SYGRAPH. Evanston, IL: SYSTAT, Inc.
Wright, S. (1932). General, group and special size factors. Genetics 17, 602619.

Relative growth of the skull and postcranium in giant transgenic mice

  • Brian T. Shea (a1), Robert E. Hammer (a2), Ralph L. Brinster (a2) and Matthew R. Ravosa (a1)

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