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Reduced pigmentation (rp), a new coat colour gene with effects on kidney lysosomal glycosidases in the mouse

Published online by Cambridge University Press:  14 April 2009

S. Gibb ,
E. M. Håkansson ,
L.-G. Lundin  and
J. G. M. Shire
S. Gibb
Affiliation:
Institute of Genetics, University of Glasgow, Glasgow G11 5JS, Scotland
E. M. Håkansson
Affiliation:
Institute for Medical Genetics, V. Agatan 24, S 75220 Uppsala, Sweden
L.-G. Lundin
Affiliation:
Institute for Medical Genetics, V. Agatan 24, S 75220 Uppsala, Sweden
J. G. M. Shire
Affiliation:
Department of Biology, University of Essex, Colchester C04 3SQ, England

Summary

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A spontaneous autosomal mutation in C57BL/Tb mice, provisionally called reduced pigmentation, symbol rp, has pronounced effects on three kidney lysosomal glycosidase activities. Homozygous rprp mice have significantly higher activities of β-galactosidase, β-glucuronidase and N-acetyl-β-hexosaminidase than their heterozygous litter-mates. Homozygotes have light ears and tails, diluted fur and dark eyes. The mutation is not allelic to any known to affect lysosomal functions, or to a number of pigmentation variants with similar phenotypic effects. The locus is on chromosome 7.

Type
Research Article
Information
Genetics Research , Volume 37 , Issue 1 , February 1981 , pp. 95 - 103
Copyright
Copyright © Cambridge University Press 1981

References

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