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Quantitative genetics and the evolution of ontogeny. III. Ontogenetic changes in correlation structure among live-body traits in randombred mice

  • James M. Cheverud (a1) and Larry J. Leamy (a2)

Summary

Ontogenetic series of phenotypic, additive genetic, maternal and environmental correlation matrices are presented and interpreted in the light of recent models for the Ontogenetic origin and variation in correlation between traits. A total of 432 mice from 108 full-sib families raised in a cross-fostering design were used to estimate the various components of phenotypic correlation for five live-body traits at eight ages. The level of genetic and phenotypic correlation decreased with age, while levels of maternal and environmental correlation remained more or less constant. Genetic correlations probably decreased due to compensatory growth. Phenotypic correlations decreased primarily due to the relative decrease in importance of highly correlated maternal effects and consequent increase in poorly correlated environmental effects as portions of phenotypic variation. The effect of compensatory growth on genetic correlation was also responsible for a portion of the decline in phenotypic correlation. Phenotypic correlation patterns remained constant over the ages studied here. It also seems likely the genetic, maternal and environmental correlation patterns do not change with age for the characters analysed.

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References

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Alberch, P. & Alberch, J. (1981). Heterochronic mechanism of morphological diversification and evolutionary change in the neotropical salamander, Bolitoglossa occidentalis. Journal of Morphology 167, 249264.
Atchley, W. (1984). Ontogeny, timing of development, and genetic variance-covariance structure. American Naturalist 123, 519540.
Atchley, W. & Rutledge, J. (1980). Genetic components of size and shape. I. Dynamics of components of phenotypic variability and covariability during ontogeny in the laboratory rat. Evolution 34, 11611173.
Atchley, W., Plummer, A. & Riska, B. (1985 a). Genetics of mandible size and shape in the mouse. Genetics (In the Press).
Atchley, W., Plummer, A. & Riska, B. (1985 b). A genetic analysis of size scaling patterns in the mouse mandible. Genetics (In the Press).
Atchley, W., Riska, B., Kohn, L., Plummer, A. & Rutledge, J. (1984). A quantitative genetic analysis of brain-body size associations, their origin and ontogeny: data from mice. Evolution 38, 11651179.
Blackith, R. & Reyment, R. (1971). Multivariate Morphometrics. New York: Academic Press.
Bonner, J. (1982). Evolution and Development. Berlin: Springer-Verlag.
Cheverud, J. (1984 a). Quantitative genetics and developmental constraints on evolution by selection. Journal of Theoretical Biology 110, 155171.
Cheverud, J. (1984 b). Evolution by kin selection: a quantitative genetic model illustrated by maternal performance in mice. Evolution 38, 766777.
Cheverud, J., Leamy, L., Atchley, W. & Rutledge, J. (1983 b). Quantitative genetics and the evolution of ontogeny. I. Ontogenetic changes in quantitative genetic variance components in randombred mice. Genetical Research, Cambridge 42, 6575.
Cheverud, J., Rutledge, J. & Atchley, W. (1983 a). Quantitative genetics of development: genetic correlations among age-specific trait values and the evolution of ontogeny. Evolution 37, 895905.
Constanzo, C., Hubert, L. & Golledge, R. (1983). A higher moment for spatial statistics. Geographical Analysis 15, 347351.
Dow, M. (1985). Nonparametric inference procedures for multistate life table analysis. Journal of Mathematical Sociology 11, 245263.
Fong, D. (1985). A quantitative genetic analysis of regressive evolution in the amphipod Gammarus minus Say. Ph.D. dissertation, Northwestern University.
Goodwin, B., Holder, N. & Wylie, C. (1983). Development and Evolution. Cambridge: Cambridge University Press.
Gould, S. (1980). Is a new and general theory of evolution emerging? Paleobiology 6, 119130.
Hayes, J. & Hill, W. (1981). Modification of estimates of parameters in the construction of genetic selection incides (‘bending’). Biometrics 37, 483493.
Helwig, J. & Council, K. (1979). SAS User's Guide. Raleigh: SAS Institute.
Hill, W. & Thompson, R. (1978). Probabilities of non-positive definite between group or genetic covariance matrices. Biometrics 34, 429439.
Hubert, L. & Schultz, J. (1976). Quadratic assignment as a general data analysis strategy. British Journal of Mathematical and Statistical Psychology 29, 190241.
Klein, T., DeFries, J. & Finkbeiner, C. (1973). Heritability and genetic correlation: standard errors of estimates and sample size. Behavior Genetics 3, 355364.
Lande, R. (1979). Quantitative genetic analysis of multivariate evolution applied to brain: body size allometry. Evolution 33, 402416.
Lande, R. (1982). A quantitative genetic theory of life history evolution. Ecology 63, 607615.
Leamy, L. & Cheverud, J. (1984). Quantitative genetics and the evolution of ontogeny. II. Genetic and environmental correlations among age-specific characters in randombred house mice. Growth 48, 339353.
Mantel, N. (1967). The detection of disease clustering and a generalized regression approach. Cancer Research 27, 209220.
Monteiro, L. & Falconer, D. (1966). Compensatory growth and sexual maturity in mice. Animal Production 8, 179182.
Oster, G. & Alberch, P. (1982). Evolution and bifurcation of developmental programs. Evolution 36, 444459.
Riska, B. & Atchley, W. (1985). Genetics and growth predict patterns of brain size evolution. Science 229, 668670.
Riska, B., Atchley, W. & Rutledge, J. (1984). A genetic analysis of targeted growth in mice. Genetics 107, 79101.
Wagner, G. (1985). On the eigenvalue distribution of genetic and phenotypic dispersion matrices: evidence for a nonrandom organization of quantitative character variation. Journal of Mathematical Biology 21, 7795.

Quantitative genetics and the evolution of ontogeny. III. Ontogenetic changes in correlation structure among live-body traits in randombred mice

  • James M. Cheverud (a1) and Larry J. Leamy (a2)

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