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Localization of the properdin factor complement locus Pfc to band A3 on the mouse X chromosome

Published online by Cambridge University Press:  14 April 2009

E. P. Evans ,
M. D. Burtenshaw ,
S. H. Laval ,
D. Goundis ,
K. B. M. Reid  and
Y. Boyd
E. P. Evans
Affiliation:
Sir William Dunn School of Pathology, South Parks Road, Oxford, U.K.
M. D. Burtenshaw
Affiliation:
Sir William Dunn School of Pathology, South Parks Road, Oxford, U.K.
S. H. Laval
Affiliation:
Genetics Division, MRC Radiobiology Unit, Chilton, Didcot, Oxon, OX11 ORD, U.K.
D. Goundis
Affiliation:
MRC Immunochemistry Unit, Department of Biochemistry, South Parks Road, Oxford, U.K.
K. B. M. Reid
Affiliation:
MRC Immunochemistry Unit, Department of Biochemistry, South Parks Road, Oxford, U.K.
Y. Boyd*
Affiliation:
Genetics Division, MRC Radiobiology Unit, Chilton, Didcot, Oxon, OX11 ORD, U.K.
*
† Corresponding author.

Summary

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The locus for properdin (properdin factor complement, Pfc), a plasma glycoprotein, has been mapped to band A3 of the mouse X chromosome by in situ hybridization to metaphase spreads containing an X;2 Robertsonian translocation. The X-linkage of the locus has also been confirmed by analysis of Mus musculus x Mus spretus interspecific crosses. The XA3 localization for Pfc places it in the chromosomal segment conserved between man and mouse which is known to contain at least six other homologous loci (Cybb, Otc, Syn-1 Maoa, Araf, Timp).

Type
Research Article
Information
Genetics Research , Volume 56 , Issue 2-3 , October 1990 , pp. 153 - 155
Copyright
Copyright © Cambridge University Press 1990

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