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Linkage mapping of sex-specific differences

  • RONGLING WU (a1), CHANG-XING MA (a1) (a2), S. S. WU (a1) and ZHAO-BANG ZENG (a3)

Abstract

Most current linkage analyses assume identical fractions of meiotic recombination between homologous marker loci of the two sexes. This assumption is not realistic, because considerable sex-related differences have been observed in recombination fraction. In this paper, a general EM-based algorithm is presented to estimate sex-specific recombination fractions for a mixed set of molecular markers segregating differently in a full-sib family derived from two heterozygous parents. The asymptotic variances of the estimates of linkage specifically for each of the parents are evaluated using a numerical analysis based on information functions. This approach will have important implications for precise gene mapping based on sex-specific linkage maps.

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Corresponding author

Corresponding author. Tel: +1 352 392 3806. Fax: +1 352 392 8555. e-mail: rwu@stat.ufl.edu

Linkage mapping of sex-specific differences

  • RONGLING WU (a1), CHANG-XING MA (a1) (a2), S. S. WU (a1) and ZHAO-BANG ZENG (a3)

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