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High genetic variability under the balance between symmetric mutation and fluctuating stabilizing selection

  • Alexey S. Kondrashov (a1) and Lev Yu. Yampolsky (a1)

Summary

We have studied variability maintained in a quantitative trait by the balance between symmetric mutation and direct stabilizing selection with a fluctuating optimum. Using a simulational computer model, we have found that wide fluctuations, such that the range of the optimum changes exceeds the width of the fitness curve, increase the trait variance, often by two or three orders of magnitude, over its value under constant selection. This happens because such fluctuations cause frequent allele substitutions at the loci that control the trait. At any particular moment the variance is increased mostly due to one or several loci where more than one allele is currently common. The data on fluctuating selection in nature are reviewed

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Corresponding author

*Corresponding author. Telephone: +1(607) 254-4221. Fax: + 1(607) 255-8088. e-mail: ask3@cornell.edu.

References

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Barton, N. H., (1986). The maintenance of polygenic variation through a balance between mutation and stabilizing selection. Genetical Research 47, 209216.
Barton, N. H., (1989). The divergence of a polygenic system subject to stabilizing selection, mutation and drift. Genetical Research 54, 5977.
Barton, N. H., & Turelli, M., (1987). Adaptive landscapes, genetic distance and the evolution of quantitative characters. Genetical Research 49, 157173.
Barton, N. H., & Turelli, M., (1989). Evolutionary quantitative genetics: how little do we know? Annual Review of Genetics 23, 337370.
Beardmore, J. A., & Levine, L., (1963). Fitness and environmental variation. I. Study of some polymorphic populations of Drosophila pseudoobscura. Evolution 17, 121129.
Bull, J. J., (1987). Evolution of phenotypic variance. Evolution 41, 303315.
Burger, R., & Lande, R., (1994). On the distribution of the mean and variance of a quantitative trait under mutation-selection-drift balance. Genetics 138, 901912.
Burger, R., & Lynch, M., (1995). Evolution and extinction in a changing environment: a quantitative-genetic analysis. Evolution 49, 151163.
Burger, R., Wagner, G. P., & Stettinger, F., (1989). How much heritable variation can be maintained in finite populations by mutation-selection balance? Evolution 43, 17481766.
Carvalho, G. R., & Crisp, D. J., (1987). The clonal ecology of Daphnia magna Crustacea: Cladocera). I. Temporal changes in the clonal structure of a natural population. Journal of Animal Ecology 56, 453468.
Charlesworth, B., (1993). Directional selection and the A. S. Kondrashov and L. Yu. Yampolsky 164 evolution of sex and recombination. Genetical Research 61, 205224.
Ellner, S., & Hairston, N. G., Jr (1994). Role of overlapping generations in maintaining genetic variation in a fluctuating environment. American Naturalist 143, 403417.
Endler, J. A., (1986). Natural Selection in the Wild. Princeton, NJ: Princeton University Press.
Gavrilets, S., (1993). Equilibria in an epistatic viability model under arbitrary strength of selection. Journal of Mathematical Biology 31, 397410.
Gavrilets, S., & Hastings, A., (1994a). Maintenance of multilocus variability under strong stabilizing selection. Journal of Mathematical Biology 32, 287302.
Gavrilets, S., & Hastings, A., (1994b). Dynamics of genetic variability in two-locus models of stabilizing selection. Genetics 138, 519532.
Gillespie, J. H., & Turelli, M., (1989). Genotype-environment interactions and the maintenance of polygenic variation. Genetics 121, 129138.
Havel, J. E., (1985). Cyclomorphosis of Daphnia pulex spined morphs. Limnology and Oceanography 30, 853861.
Hill, W. G., & Keightley, P. D., (1988). Interrelations of mutation, population size, artificial and natural selection. In Proceedings of the Second International Conference on Quantitative Genetics (ed. Weir, B. S., Eisen, E. J., Goodman, M. M. & Namkoong, G.), pp. 5770. Sunderland: Sinauer.
Houle, D., (1989). The maintenance of polygenic variation in finite populations. Evolution 43, 17671780.
Kirzhner, V. M., Korol, A. B., Ronin, Y. I., & Nevo, E., (1994). Cyclical behavior of genotype frequencies in a two-locus population under fluctuating haploid selection. Proceedings of the National Academy of Sciences of the USA 91, 1143211436.
Kirzhner, V. M., Korol, A. B., & Ronin, Y. I., (1995). Cyclical environmental changes as a factor maintaining genetic polymorphism. I. Two-locus haploid selection. Journal of Evolutionary Biology 8, 93120.
Kondrashov, A. S., (1984). Rate of evolution in a changing environment. Journal of Theoretical Biology 107, 249260.
Kondrashov, A. S., & Turelli, M., (1992). Deleterious mutations and apparent stabilizing selection in quantitative traits. Genetics 132, 603618.
Kondrashov, A. S., & Yampolsky, L. Yu. (1996). Evolution of amphimixis and recombination under fluctuating genetic selection in one and many traits. Genetical Research6S, 165173.
Korol, A. B., & Preygel, I. A., (1989). The increase of recombination in the multilocus system under changing environment. Genetika 25, 923931.(in Russian).
Lande, R., (1975). The maintenance of genetic variability by mutation in a polygenic character with linked loci. Genetical Research 26, 221235.
Lande, R., (1977). The influence of the mating system on the maintenance of genetic variability in polygenic characters. Genetics 86, 485498.
Lee, L. W., (1984). Environmentally controlled phenotypic plasticity of morphology and polypeptide expression in two populations of Daphniapulex (Crustacea: Cladocera). Oecologia (Berlin) 63, 207214.
Lewontin, R. C., (1964). The interaction of selection and linkage. II. Optimum models. Genetics 50, 757782.
Lorenzi, R., Zonta, L. A., & Jayakar, S. D., (1989). Quantitative traits and temporally variable selection: two-locus models. Journal of Genetics 68, 2942.
Lynch, M., (1987). The consequences of fluctuating selection for isozyme polymorphisms in Daphnia. Genetics 115, 657670.
Mackay, T. F. C., (1980). Genetic variance, fitness, and homeostasis in varying environment: an experimental check of the theory. Evolution 34, 12191222.
Mackay, T. F. C., (1981). Genetic variation in varying environments. Genetical Research 37, 7983.
Smith, J. Maynard, (1978). The Evolution of Sex. Cambridge: Cambridge University Press.
Smith, J. Maynard, (1980). Selection for recombination in a polygenic model. Genetical Research 35, 269277.
Smith, J. Maynard, (1988). Selection for recombination in a polygenic model: the mechanism. Genetical Research 51, 5963.
Nei, M. & Graur, D., (1984). Extent of protein polymorphism and the neutral mutation theory. Evolutionary Biology 17, 73118.
Nevo, E., Beiles, A., & Ben-Shlomo, R., (1984). The evolutionary significance of genetic diversity: ecological, demographic and life history correlates. Lecture Notes in Biomathematics 53, 13213.
Parejko, K., & Dodson, S.I. (1991). The evolutionary ecology of an antipredator reaction norm: Daphnia pulex and Chaoborus americanus. Evolution 45, 16651674.
Rutchman, D. H., (1994). Dynamics of the two-locus haploid model. Theoretical Population Biology 45, 167176.
Scheiner, S. M., (1993). Genetics and evolution of phenotypic plasticity. Annual Review of Ecology and Systematics 24, 3568.
Slatkin, M., (1979). Frequency- and density-dependent selection on a quantitative character. Genetics 93, 755771.
Threlkeld, S. T., (1987). Daphnia life history strategies and resource allocation patterns. Memorie dellIstituto Italiano di Idrobiologia 45, 353366.
Turelli, M., (1984). Heritable genetic variation via mutation-selection balance: Lerch's zeta meets the abdominal bristle. Theoretical Population Biology 25, 138193.
Turelli, M., (1988). Population genetic models for polygenic variation and evolution. In Proceedings of the Second International Conference on Quantitative Genetics (ed. Weir, B. S., Eisen, E. J., Goodman, M. M. & Namkoong, G.), pp. 601608. Sunderland: Sinauer.
Yampolsky, L. Yu. & Ebert, D., (1994). Variation and plasticity of biomass allocation in Daphnia. Functional Ecology 8, 435440.
Zeng, Z.-B. & Cockerham, C. C., (1993). Mutation models and quantitative genetic variation. Genetics 133, 729736.

High genetic variability under the balance between symmetric mutation and fluctuating stabilizing selection

  • Alexey S. Kondrashov (a1) and Lev Yu. Yampolsky (a1)

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