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The gene controlling the binding sites of Dolichos biflorus agglutinin, Dlb-1, is on chromosome 11 of the mouse

Published online by Cambridge University Press:  14 April 2009

H. G. Uiterdijk ,
B. A. J. Ponder ,
M. F. W. Festing ,
J. Hilgers ,
L. Skow  and
R. Van Nie
H. G. Uiterdijk
Affiliation:
Division of Tumor Biology, The Netherlands Cancer Institute Antoni van Leeuwenhoekhuis, Amsterdam, The Netherlands
B. A. J. Ponder
Affiliation:
Institute of Cancer Research, Haddow Laboratories, Sutton, Surrey, U.K.
M. F. W. Festing
Affiliation:
MRC Experimental Embryology and Teratology Unit, Carshalton, Surrey, U.K.
J. Hilgers
Affiliation:
Division of Tumor Biology, The Netherlands Cancer Institute Antoni van Leeuwenhoekhuis, Amsterdam, The Netherlands
L. Skow
Affiliation:
National Institute of Environmental Health Sciences, Research Triangle Park, N.C., U.S.A.
R. Van Nie
Affiliation:
Division of Tumor Biology, The Netherlands Cancer Institute Antoni van Leeuwenhoekhuis, Amsterdam, The Netherlands
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Summary

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A locus, Dlb-1, controlling the binding of the lectin from Dolichos biflorus to the intestinal epithelium and vascular endothelium of mice has been located on chromosome 11, 3.1 ± 1.4 centimorgans proximal to Rex, using recombinant inbred strains and conventional backcrosses with three-point linkage tests.

The two alleles so far discovered at this locus behave unusually. The Dlb-1a allele causes binding to the vascular endothelium but not to the intestinal epithelium while Dlb-1b induces the exact reciprocal binding pattern, and the heterozygote shows both patterns.

Type
Research Article
Information
Genetics Research , Volume 47 , Issue 2 , April 1986 , pp. 125 - 129
Copyright
Copyright © Cambridge University Press 1986

References

Green, M. C. (1981). Catalog of mutant genes and polymorphic loci. In Genetic Variants and Strains of the Laboratory Mouse (ed. Green, M. C.), pp. 9–278. Stuttgart, New York: Gustav Fischer-Verlag.Google Scholar
Hilgers, J. & Arends, J. (In the Press). A series of recombinant inbred strains between the BALB/cHeA and STS/A mouse strains. In The Novel immunological responses of the BALB/c mouse. (ed. Potter, M.). New York: Springer-Verlag.Google Scholar
Hoffman, H. A. (1975). Qualitative characters in genetic monitoring. In ICLAS Manual for Genetic Monitoring of Inbred Mice (ed. Nomura, T., Esaki, K. and Tomita, T.), pp. 38–110. Tokyo: University of Tokyo Press.Google Scholar
Ponder, B. A. J. & Wilkinson, M. M. (1983). Organ-related differences in binding of Dolichos biflorus agglutinin to vascular endothelium. Developmental Biology 96, 535–541.CrossRefGoogle ScholarPubMed
Ponder, B. A. J., Festing, M. F. W. & Wilkinson, M. M. (1985). An allelic difference determines reciprocal patterns of expression of binding sites for Dolichos biflorus lectin in inbred strains of mice. Journal of Experimental Embryology and Morphology 87, 229–239.Google ScholarPubMed
Roderick, T. H., Hulton, J. J. & Ruddle, F. H. (1970). Linkage of Esterase-3 and Rex on linkage group VII of the mouse. Journal of Heredity 61, 278.CrossRefGoogle ScholarPubMed
Roderick, T. H. & Davisson, M. T. (1981). Linkage map. In Genetic Variants and Strains of the Laboratory Mouse, (ed. Green, M. C.), pp. 279–313. Stuttgart, New York: Gustav Fischer-Verlag.Google Scholar
Taylor, B. A. (1981). Recombinant inbred strains. In Genetic Variants and Strains of the Laboratory Mouse, (ed. Green, M. C.), pp. 397–407. Stuttgart, New York: Gustav Fischer-Verlag.Google Scholar
Uiterdijk, H. G. & Ponder, B. A. J. (1985). The binding of Dolichos biflorus agglutinin to vascular endothelium and intestinal epithelium of mice, a genetic dimorphism. In Lectins, biology, biochemistry, clinical biochemistry, vol. 4. (ed. Bøg-Hansen, T. C. and Breborowicz, J.), pp. 161–168. Berlin: W. de Gruyter.Google Scholar
Whitney, J. B., Copeland, G. T., Skow, L. C. & Russell, E. S. (1979). Resolution of products of the duplicated hemoglobin alpha-chain loci by isoelectric focussing. Proceedings of the National Academy of Sciences, U.S.A. 76, 867–871.CrossRefGoogle Scholar