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The effect of selection on genetic variability: a simulation study

  • M. G. Bulmer (a1)

Summary

Computer simulations have been done to study the effects of stabilizing and disruptive selection on a polygenic character. The results are reported in terms of three components of genetic variability which represent changes in gene frequencies, departures from Hardy–Weinberg equilibrium and linkage disequilibrium respectively. Under random mating the first and third components are the most important. The observed changes in gene frequencies are interpreted in the light of previous theoretical work on the stability of equilibria under selection. In addition, large and rapid changes in the genotypic variance result from the generation of linkage disequilibrium under selection; the observed changes are in good agreement with those predicted on theoretical grounds.

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References

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Bulmer, M. G. (1971 a). The stability of equilibria under selection. Heredity 27, 157162.
Bulmer, M. G. (1971 b). The effect of selection on genetic variability. American Naturalist 105, 201211.
Bulmer, M. G. (1974 a). Density-dependent selection and character displacement. American Naturalist 108, 4558.
Bulmer, M. G. (1974 b). Linkage disequilibrium and genetic variability. Genet. Res. 23, 281289.
Falconer, D. S. (1957). Selection for phenotypic intermediates in Drosophila. J. Genet. 55, 551561.
Falconer, D. S. (1960). Introduction to Quantitative Genetics. Edinburgh: Oliver and Boyd.
Hill, W. G. (1974). Disequilibrium among several linked neutral genes in finite populations. II. Variances and covariances of disequiibria. Theor. Pop. Biol. 6, 184198.
Hill, W. G. & Robertson, A. (1968). Linkage disequilibrium in finite populations. Theor. Appl. Genet. 38, 226231.
Roughgarden, J. (1972). Evolution of niche width. American Naturalist 106, 683718.
Slatkin, M. (1970). Selection and polygenic characters. Proc. Nat. Acad. Sci. 66, 8793.

The effect of selection on genetic variability: a simulation study

  • M. G. Bulmer (a1)

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