Hostname: page-component-848d4c4894-sjtt6 Total loading time: 0 Render date: 2024-06-26T20:57:14.270Z Has data issue: false hasContentIssue false
  • English
  • Français

Chromosomal analysis of cultured skin fibroblasts from patients with infectious mononucleosis

Published online by Cambridge University Press:  14 April 2009

Patricia L. Monteleone ,
James D. Cherry  and
James A. Monteleone
Patricia L. Monteleone
Affiliation:
Department of Pediatrics, St Louis University School of Medicine, and the Genetics and Infectious Disease Units, Cardinal Glennon Memorial Hospital For Children
James D. Cherry
Affiliation:
Department of Pediatrics, St Louis University School of Medicine, and the Genetics and Infectious Disease Units, Cardinal Glennon Memorial Hospital For Children
James A. Monteleone
Affiliation:
Department of Pediatrics, St Louis University School of Medicine, and the Genetics and Infectious Disease Units, Cardinal Glennon Memorial Hospital For Children

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

In the present study, skin fibroblasts and leukocyte cultures from patients with acute infectious mononucleosis were examined to determine if any in vitro marker chromosomes could be detected. No alterations in chromosomes could be found in fibroblasts either from the region of the typical rash or from other areas of skin. This would tend to suggest but does not necessarily prove that this tissue was not extensively involved in the disease process.

Type
Short Papers
Information
Genetics Research , Volume 16 , Issue 3 , December 1970 , pp. 345 - 348
Copyright
Copyright © Cambridge University Press 1970

References

REFERENCES

Henle, G., Henle, W. & Diehl, V. (1968). Relation of Burkitt's tumor-associated herpes-type virus to infectious mononucleosis. Proceedings of the National Academy of Science, U.S.A. 59, 94–101.CrossRefGoogle Scholar
Kohn, G., Diehl, V., Mellman, W., Henle, W. & Henle, G. (1968). C-Group chromosome marker in long-term leukocyte cultures. Journal of the National Cancer Institute 41, 795–804.Google ScholarPubMed
Kohn, G., Mellman, W., Moorhead, P., Loftus, J. & Henle, G. (1967). Involvement of C group chromosomes in five Burkitt lymphoma cell lines. Journal of National Cancer Institute 38, 209–222.Google ScholarPubMed
Miles, C. & O'Neill, F. (1967). Chromosome studies of 8 in vitro lines of Burkitt's lymphoma. Cancer Research 27, 392–402.Google ScholarPubMed
Monteleone, P., Durst, J. & Cherry, J. (1968). Simplified culture of human skin fibroblasts for chromosomal analysis. Health Laboratory Science 5, 257–258.Google Scholar
Niederman, J., McCollum, R., Henle, G. & Henle, W. (1968). Infectious mononucleosis. Journal of the American Medical Association 203, 205–209.CrossRefGoogle ScholarPubMed
Pope, J. (1967). Establishment of cell lines from peripheral leukocytes in infectious mononucleosis. Nature 216, 810–811.CrossRefGoogle ScholarPubMed