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Can segregation distortion influence gametic disequilibrium?

Published online by Cambridge University Press:  14 April 2009

Philip W. Hedrick
Philip W. Hedrick
Affiliation:
Department of Biology, Pennsylvania State University, University Park, Pennsylvania 16802, U.S.A.
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There are a number of reports of gametic disequilibrium between alleles causing segregation distortion (e.g. t alleles in M. musculus and SD alleles in D. melanogaster) and linked loci. These observations have resulted in the conclusion by some researchers that segregation distortion may cause gametic disequilibrium. In this manuscript I have shown that (1) segregation distortion cannot generate gametic disequilibrium de novo and (2) because segregation distortion results in an excess of heterozygotes, the rate of decay of disequilibrium is faster than if segregation distortion were absent. Other factors, such as mutation or selection, appear to generate the observed disequilibrium, and extremely low recombination appears important in retarding its decay.

Type
Research Article
Information
Genetics Research , Volume 52 , Issue 3 , December 1988 , pp. 237 - 242
Copyright
Copyright © Cambridge University Press 1988

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