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The ductus arteriosus

Published online by Cambridge University Press:  10 October 2008

Jim van Eyck
Jim van Eyck*
Affiliation:
Department of Obstetrics and Gynaecology, Academic Hospital Rotterdam – Dijkzigt, Erasmus University, Rotterdam, The Netherlands
*
Jim van Eyck, Academic Hospital Rotterdam – Dijkzigt, Department of Obstetrics and Gynaecology, Erasmus University Rotterdam, Dr. Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
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Extract

The ductus arteriosus is a large vessel which connects the pulmonary trunk with the aorta. During fetal life it serves together with the foramen ovale as a shunt at cardiac level. Due to a complex regulatory mechanism it is capable of maintaining patency during fetal life and of rapid closure after birth. However, in premature neonates ductal patency frequently persists, an occurrence which may even be favourable in some situations. Recent investigations on the ductus arteriosus have provided new information about the regulatory mechanisms involved with its function. Initially, most studies on the fetal ductus arteriosus were conducted in animals. With the introduction of the combined use of two dimensional real-time and Doppler ultrasound systems the opportunity became available to study blood flow within the ductus arteriosus in the human fetus and neonate in a noninvasive manner. The increasing use in obstetric care of cyclo-oxygenase inhibitors for tocolysis and for prevention of the development of pregnancy induced hypertension and pre-eclampsia justifies the re-evaluation of the potential adverse effects of these drugs on the ductus arteriosus.

Type
Articles
Information
Fetal and Maternal Medicine Review , Volume 2 , Issue 2 , July 1990 , pp. 207 - 223
Copyright
Copyright © Cambridge University Press 1990

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References

Heymann, MA, Creasy, RK, Rudolph, AM. Quantitation of blood flow patterns in the fetal lamb in utero. In: Foetal and neonatal physiology: proceedings of the Sir Joseph Barcroft Centenary Symposium Cambridge: Cambridge University Press, 1973: 129–35.Google Scholar
Heymann, MA, Rudolph, AM. Control of the ductus arteriosus. Physiol Rev 1975; 55: 62–78.CrossRefGoogle ScholarPubMed
Rudolph, AM, Heymann, MA. Circulatory changes during growth in the fetal lamb. Circ Res 1970; 26: 289–99.CrossRefGoogle ScholarPubMed
Coceani, F, Olley, PM. Considerations on the role of prostaglandin in the ductus arteriosus. In: Samuelsson, B, Ramwell, RW, Paoletti, R eds, Advances in prostaglandin and thromboxane research, Volume 7, New York: Raven Press, 1980: 871–78.Google Scholar
Sideris, EB, Yokochi, K, Van Helder, T, Coceani, F, Olley, PM. Effects on indomethacin and prostaglandin E2, I2 and D2 on the fetal circulation. Adv Prostaglandin, Thromboxane Leukotriene Res 1983; 12: 477–82.Google ScholarPubMed
Clyman, RI, Mauray, F, Roman, C, Heymann, MA, Payne, B. Factors determining the loss of ductus arteriosus responsiveness to prostaglandin E. Circulation 1983; 68: 433–36.CrossRefGoogle ScholarPubMed
Coceani, F, Bishai, I, White, E, Bodach, E, Olley, PM. Actions of prostaglandins, endoperoxides and thromboxanes on the lamb ductus arteriosus. Am J Physiol 1978; 234: H117–22.Google ScholarPubMed
Clyman, RI, Mauray, F, Roman, C, Rudolph, AM. PGE2 is a more potent vasodilator of the lamb ductus arteriosus than is either PGI2 or 6-keto-PGF1α. Prostaglandins 1978; 16: 259–64.CrossRefGoogle ScholarPubMed
Coceani, F, Bodach, E, White, E, Bishai, I, Olley, PM. Prostaglandin I2 is less relaxant than prostaglandin E2 in the lamb ductus arteriosus. Prostaglandins 1978; 14: 551–56.CrossRefGoogle Scholar
Friedman, WF, Printz, MP, Kirkpatrick, SE, Hoskins, EJ. The vasoactivity of the fetal lamb ductus arteriosus studied in utero. Pediatr Res 1983; 17: 331–38.CrossRefGoogle ScholarPubMed
Friedman, WF, Hirschklau, MJ, Printz, MP et al. Pharmacologic closure of the patent ductus arteriosus in the preterm infant. N Engl J Med 1976; 295: 526–29.CrossRefGoogle Scholar
Heymann, MA, Rudolph, AM. Effect of acetylsalicylic acid on the ductus arteriosus and circulation in fetal lambs in utero. Circ Res. 1976; 38: 418–22.CrossRefGoogle ScholarPubMed
Sharpe, GL, Larsson, KS, Thalme, B. Studies on the closure of the ductus arterious. XII. In utero effects of indomethacin and sodium salicylate in rats and rabbits. Prostaglandins 1975; 9: 585–96.CrossRefGoogle Scholar
Clyman, RI. Developmental response to oxygen, arachidonic acid, and indomethacin in the fetal lamb ductus in vitro. Prostaglandins and Medicine 1978; 1: 167–74.CrossRefGoogle ScholarPubMed
Coceani, F, Olley, PM, Bodach, E. Lamb ductus arteriosus. Effects of prostaglandin synthesis inhibitors on the muscle tone and the response to prostaglandin E2. Prostaglandins 1975; 9: 299–308.CrossRefGoogle ScholarPubMed
Sideris, EB, Yokochi, K, Coceani, F, Olley, PM. Prostaglandins and fetal cardiac output distribution in the lamb. Am J Physiol 1985; 248: H853–58.Google ScholarPubMed
Coceani, F, Olley, PM. Role of prostaglandins, prostacyclin, and thromboxanes in the control of prenatal patency and postnatal closure of the ductus arteriosus. In: Heymann, MA, ed, Prostaglandins in the perinatal period, New York: Grune & Stratton, 1980: 109–13.Google Scholar
Terragno, NA, Terragno, A. Prostaglandin metabolism in the fetal and maternal vasculature. Fed Proc 1979; 38: 75–77.Google ScholarPubMed
Pace-Asciak, CR, Rangaraj, G. The 6 keto prostaglandin F1α pathway in the lamb ductus arteriosus. Biochim Biophys Acta 1977; 486: 583–85.CrossRefGoogle Scholar
Powell, WS, Solomon, S. Formation of 6-oxoprostaglandin F1α by arteries of the fetal calf. Biochem Biophys Res Commun 1977; 75: 815–22.CrossRefGoogle Scholar
Coceani, F, Huhtanen, D, Hamilton, NC, Bishai, I, Olley, PM. Involvement of intramural prostaglandin E2 in prenatal patency of the lamb ductus arteriosus. Can J Physiol Pharmacol 1986; 64: 737–44.CrossRefGoogle ScholarPubMed
Bunting, S, Gryglewski, RJ, Moncada, S et al. Arterial walls generate from prostaglandin endoperoxides a substance which relaxes strips of mesenteric and coeliac arteries and inhibits platelet aggregation. Prostaglandins 1976; 12: 897–913.CrossRefGoogle ScholarPubMed
Omini, C, Moncada, S, Vane, JR. The effects of prostacyclin on tissues which detect prostaglandins. Prostaglandins 1977; 14: 625–32.CrossRefGoogle ScholarPubMed
Moncada, S. 1977 Winter Prostaglandin Conference, Vail, Colorado, Session IV. Prostaglandins 1977; 14: 205.Google Scholar
Coceani, F, Olley, PM. The response of the ductus arteriosus to prostaglandins. Can J Physiol Pharmacol 1973; 51: 220–25.CrossRefGoogle ScholarPubMed
Clyman, RI. Ontogeny of the ductus arteriosus response to prostaglandins and inhibitors of their synthesis. Semin Perinatol 1980; 4: 115–24.Google ScholarPubMed
Coceani, F, Olley, PM, Bishai, I, Bodach, E, White, EP. Significance of the control of the prostaglandin system to the control of muscle tone of the ductus arteriosus. In: Coceani, F, Olley, PM, eds, Advances in prostaglandin and thromboxane research, Volume 4, Raven Press: New York, 1978: 325–33.Google Scholar
Friedman, WF, Molony, DA, Kirkpatrick, SE. Prostaglandins: physiological and clinical correlation. In: Barnes, L ed, Advances in pediatrics, Volume 25, Chicago: Yearbook, 1978: 151–204.Google Scholar
Challis, JRG, Patrick, JE. The production of prostaglandins and thromboxanes in the fetoplacental unit and their effects on the developing fetus. In: Heyman, MA ed, Prostaglandins in the perinatal period, New York: Grune & Stratton, 1980, 23–33.Google Scholar
Lucas, A, Mitchell, MD. Plasma prostaglandins in preterm neonates before and after treatment for patent ductus arteriosus. Lancet 1978; 2: 130–34.CrossRefGoogle Scholar
Lucas, A, Mitchell, MD. Prostaglandins in patent ductus arteriosus. Lancet 1978; 2: 937–40.CrossRefGoogle Scholar
Green, TP, Thompson, TR, Johnson, DE, Lock, JE. Furosemide promotes patent ductus arteriosus in premature infants with the respiratory distress syndrome. N Engl J Med 1983; 308: 743–47.CrossRefGoogle ScholarPubMed
Piper, PJ, Vane, JR, Wyllie, JH. Inactivation of prostaglandins by the lungs. Nature 1970; 225: 600–604.CrossRefGoogle ScholarPubMed
Ferreira, SH, Vane, JR. Prostaglandins: their disappearance from and release into the circulation. Nature 1967; 216: 868–73.CrossRefGoogle ScholarPubMed
McGiff, JC, Terragno, NA, Strand, JC et al. Selective passage of prostaglandins across the lung. Nature 1969; 223: 742–45.CrossRefGoogle ScholarPubMed
Pace-Asciak, CR, Rangaraj, G. Prostaglandin biosynthesis and catabolism in the lamb ductus arteriosus, aorta and pulmonary artery. Biochem Biophys Acta 1978; 529: 13–20.CrossRefGoogle ScholarPubMed
Powell, WS, Solomon, S. Biosynthesis of prostaglandins and thromboxanes in fetal tissue. In: Coceani, F, Olley, PM eds, Advances in prostaglandin and thromboxane research, Volume 4, New York: Raven Press, 1978: 61–74.Google Scholar
Clyman, RI, Mauray, F, Rudolph, AM, Heymann, MA. Age-dependent sensitivity of the lamb ductus arteriosus to indomethacin and prostaglandins. J Pediatr 1980; 96: 94–98.CrossRefGoogle ScholarPubMed
Coceani, F, White, E, Bodach, E, Olley, PM. Age-dependent changes in the response of the lamb ductus arteriosus to oxygen and ibuprofen. Can J Physiol Pharmacol 1979; 57: 825–31.CrossRefGoogle ScholarPubMed
Sharpe, GL, Larsson, KS. Studies on closure of the ductus arteriosus. X. In vivo effects of prostaglandins. Prostaglandins 1975; 9: 703–709.CrossRefGoogle Scholar
Heymann, MA, Rudolph, AM. Effects of prostaglandins and blockers of prostaglandin synthesis on the ductus arteriosus: animal and human studies. In: Coceani, F, Olley, PM eds,Advances in prostaglandin and thromboxane research, Volume 4, New York: Raven Press, 363–72.Google Scholar
Clyman, RI, Heymann, MA, Rudolph, AM. Ductus arteriosus responses to prostaglandins E1 at high and low oxygen concentrations. Prostaglandins 1977; 13: 219–23.CrossRefGoogle ScholarPubMed
Clyman, RI, Wong, L, Heymann, MA et al. Responsiveness of the lamb ductus arteriosus to prostaglandins and their metabolites. Prostaglandins 1978; 15: 325–31.CrossRefGoogle ScholarPubMed
Olley, PM, Coceani, F. Lipid mediator in the control of the ductus arteriosus. Am Rev Respir Dis 1987; 136: 218–19.CrossRefGoogle ScholarPubMed
Coceani, F, Breen, CA, Lees, JG, Falck, JR, Olley, PM. Further evidence implicating a cytochrome P-450-mediated reaction in the contractile tension of the lamb ductus arteriosus. Circ Res 1988; 62: 471–77.CrossRefGoogle ScholarPubMed
Kramer, GL, Hardman, JG. Cyclic nucleotides and blood vessel contraction. In: Bohr, DF, Somlyo, AP, Sparks, HV Jr eds, Handbook of physiology, Section 2, Volume 2, Vascular smooth muscle. Bethesda: American Physiological Society, 1980: 179–99.Google Scholar
Kukovetz, WR, Poch, G, Holzman, S. Cyclic nucleotides and relaxation of vascular smooth muscle. In: Vanhoutte, PM, Leusden, I eds, Vasodilatation, New York: Raven Press, 1981: 339–53.Google Scholar
Clyman, RI, Sandier, JA, Mangiello, VC, Vaughan, M. Guanosine 3′, 5′-monophosphate and adenosine 3′,5′-monophosphate content of human umbilical artery. J Clin Invest 1975; 55: 1020–25.CrossRefGoogle ScholarPubMed
Kadowitz, PJ, Joiner, PD, Hayman, AL, George, WJ. Influence of prostaglandins E1 and F2 on pulmonary vascular resistance, isolated lobar vessels, and cyclic nucleotide levels. J Pharmacol Exp Ther 1975; 192: 677–87.Google Scholar
Mentzer, RM, Ely, SW, Lasley, RD et al. Hormonal role of adenosine in maintaining patency of the ductus arteriosus in fetal lambs. Ann Surg 1985; 202: 223–30.CrossRefGoogle ScholarPubMed
Levin, DL. Effect of inhibition of prostaglandin synthesis on fetal development, oxygenation, and the fetal circulation. Semin Perinatol 1980; 4: 35–44.Google ScholarPubMed
Levin, DL, Mills, LJ, Parkey, M, Garriott, J, Campbell, W. Constriction of the fetal ductus arteriosus after administration of indomethacin to the pregnant ewe. J Pediatr 1979; 94: 647–50.CrossRefGoogle Scholar
Truter, PJ, Franszen, S, Van der Merwe, JV, Coetzee, MJ. Premature closure of the ductus arteriosus causing intra-uterine death. A case report. S Afr Med J 1986; 70: 557–58.Google ScholarPubMed
Arcilla, RA, Thilenius, OG, Ranniger, K. Congestive heart failure from suspected ductal closure in utero. J Pediatr 1969; 75: 74–78.CrossRefGoogle ScholarPubMed
Dudley, DKL, Hardie, MJ, Fetal and neonatal effects of indomethacin used as a tocolytic agent. Am J Obstet Gynecol 1985; 151: 181–84.CrossRefGoogle ScholarPubMed
Niebyl, JR, Blake, DA, White, RD et al. The inhibition of premature labor with indomethacin. Am J Obstet Gynecol 1980; 136: 1014–19.CrossRefGoogle ScholarPubMed
Niebyl, JR, Witter, FR. Neonatal outcome after indomethacin treatment for preterm labor. Am J Obstet Gynecol 1986; 155: 747–49.CrossRefGoogle ScholarPubMed
Wallenburg, HCS, Makovitz, JW, Dekker, GA, Rotmans, P. Low-dose aspirin prevents pregnancy-induced hypertension and preeclampsia in angiotensin-sensitive primigravidae. Lancet 1986; 1: 1–3.CrossRefGoogle ScholarPubMed
Wallenburg, HCS, Rotmans, N. Prevention of recurrent idiopathic fetal growth retardation by low-dose aspirin and dipyridamole. Am J Obstet Gynecol 1987; 157: 1230–35.CrossRefGoogle ScholarPubMed
Branch, DW, Scott, JR, Kochenour, NK, Hershgold, E. Obstetric complications associated with the lupus anticoagulant. N Engl J Med 1985; 313: 1322–36.CrossRefGoogle ScholarPubMed
Cabrol, D, Landesman, R, Muller, J et al. Treatment of polyhydramnios with prostaglandin synthetase inhibitor (indomethacin). Am J Obstet Gynecol 1987; 157: 422–26.CrossRefGoogle ScholarPubMed
Kirshon, B, Moise, KJ, Wasserstrum, N, Ching-Nan, Ou, Huhta, JC. Influence of short-term indomethacin therapy on fetal urine output. Obstet Gynecol 1988; 72: 51–53.Google Scholar
De Wit, W, Van Mourik, I, Wiesenhaan, PF. Prolonged maternal indomethacin therapy associated with oligohydramnios. Case reports. Br J Obstet Gynaecol 1988; 95: 303–305.CrossRefGoogle ScholarPubMed
Traeger, A, Noschel, H, Zaumseil, J. The pharmacokinetics of indomethacin in pregnant and parturient women and in their newborn infants. Zentralbl Gynakol 1973; 95: 635–40.Google ScholarPubMed
Parks, BR, Jordan, RL, Rawson, JE, Douglas, BH. Indomethacin: studies of absorption and placental transfer. Am J Obstet Gynecol 1977; 129: 464–65.CrossRefGoogle ScholarPubMed
Rumack, CM, Guggenheim, MA, Rumack, BH, Peterson, RG, Johnson, ML, Braithwaite, WR. Neonatal intracranial hemorrhage and maternal use of aspirin. Obstet Gynecol 1981; 58: 52S–56S.Google ScholarPubMed
Bat, R, Vidyasagar, D, Vadapalli, MD et al. Disposition of indomethacin in preterm infants. J Pediatr 1979; 95: 313–16.Google Scholar
Levy, G, Garrettson, LK. Kinetics of salicylate elimination by newborn infants of mothers who ingested aspirin before delivery. Pediatrics 1974; 53: 201–10.CrossRefGoogle ScholarPubMed
Starling, MB, Elliott, RB. The effects of prostaglandin inhibitors, and oxygen on the closure of the ductus arteriosus, pulmonary arteries and umbilical vessels in vitro. Prostaglandins 1974; 8: 187–203.CrossRefGoogle ScholarPubMed
Sharpe, GL, Thalme, B, Larsson, KS. Studies on closure of the ductus arteriosus. XI. Ductal closure in utero by a prostaglandin synthetase inhibitor. Prostaglandins 1974; 8: 363–68.CrossRefGoogle ScholarPubMed
Olley, PM, Bodach, E, Heaton, J et al. Further evidence implicating E-type prostaglandins in the patency of the lamb ductus arteriosus. Eur J Pharmacol 1975; 34: 247–60.CrossRefGoogle ScholarPubMed
Kirkpatrick, SE, Printz, MF, Friedman, WF. Prostaglandins and the fetal ductus arteriosus. Pediatr Res 1977; 11: 395–99.Google Scholar
Levin, DL, Mills, LJ, Weinberg, AG et al. Hemodynamic, pulmonary vascular, and myocardial abnormalities secondary to pharmacologic constriction of the fetal ductus arteriosus: a possible mechanism for persistent pulmonary hypertension and transient tricuspid insufficiency in the newborn infant. Circulation 1979; 60: 360–64.CrossRefGoogle ScholarPubMed
Spearing, G. Alcohol, indomethacin and salbutamol: a comparative trial on their use in preterm labor. Obstet Gynecol 1979; 53: 171–74.Google ScholarPubMed
Atad, J, David, A, Moise, J et al. Classification of threatened premature labor related to treatment with a prostaglandin inhibitor: indomethacin Biol Neonate 1980; 37: 291–95.CrossRefGoogle ScholarPubMed
Niebyl, JR, Dillard, T, Witter, FR et al. Treatment of preterm labor with indomethacin (Abstract). In: Proceedings of the 6th Annual Meeting of the Society of Perinatal Obstetricians, San Antonio, 1986.Google Scholar
Wiqvist, N. Preterm labor: other drug possibilities including drugs not to use. In: Elder, MG, Hendricks, CH eds, Preterm labor, London: Butterworth, 1981: 148–75.Google Scholar
Van Kets, H, Thiery, M, Deron, R, Van Egmond, H, Baele, G. Perinatal hazards of chronic antenatal tocolysis with indomethacin. Prostaglandins 1979; 18: 893–907.CrossRefGoogle ScholarPubMed
Sharpe, GL. Indomethacin and closure of the ductus arteriosus. Lancet 1975; 1: 693–96.CrossRefGoogle ScholarPubMed
Momma, K, Takao, A. In vivo constriction of the ductus arteriosus by non-steroidal anti-inflammatory drugs in near-term and preterm fetal rats. Pediatr Res 1987; 22: 567–72.CrossRefGoogle ScholarPubMed
Gersony, WM, Peckham, GJ, Ellison, RC, Miettinen, OS, Nadat, AS. Effects of indomethacin in premature infants with patent ductus arteriosus: results of a national collaborative study. J Pediatr 1983; 102: 895–906.CrossRefGoogle ScholarPubMed
Moise, KH, Huhta, JC, Sharif, DS. Indomethacin in the treatment of premature labor. Effects on the fetal ductus arteriosus. N Engl J Med 1988; 319: 327–31.CrossRefGoogle ScholarPubMed
Heymann, MA, Rudolph, AM, Silverman, NH. Closure of the ductus arteriosus in premature infants by inhibition of prostaglandin synthesis. N Engl J Med 1976; 295: 530–33.CrossRefGoogle ScholarPubMed
Momma, K, Hagiwara, H, Konoshi, T. Constriction of fetal ductus arteriosus by non-steroidal anti-inflammatory drugs: study of additional 34 drugs. Prostaglandins 1984; 28: 527–36.CrossRefGoogle ScholarPubMed
Momma, K, Takeuchi, H. Constriction of fetal ductus arteriosus by non-steroidal anti-inflammatory drugs. Prostaglandins 1983; 26: 631–43.CrossRefGoogle ScholarPubMed
Gittenberger-de Groot, AC, Van, Ertbruggen I, Moulaert, AJMG et al. The ductus arteriosus in the preterm infant: histologic and clinical observations. J Pediatr 1980; 96: 88–91.CrossRefGoogle ScholarPubMed
Strauss, A, Modanlou, HD, Gyepes, M et al. Congenital heart disease and respiratory distress syndrome. Reversal of indomethacin closure of patent ductus arteriosus by prostaglandin therapy in a preterm infant. Am J Dis Child 1982; 136: 934–37.CrossRefGoogle Scholar
Momma, K, Konishi, T, Hagiwara, H. Characteristic morphology of the constricted fetal ductus arteriosus following maternal administration of indomethacin. Pediatr Res 1985; 19: 493–500.CrossRefGoogle ScholarPubMed
Demello, DE, Murphy, JD, Aronovitz, MJ, Davies, P, Reid, LM. Effects of indomethacin in utero on the pulmonary vasculature of the newborn guinea pig. Pediatr Res 1987; 22: 693–97.CrossRefGoogle ScholarPubMed
Levin, DL, Fixler, DE, Morriss, FC, Tyson, J. Morphologic analysis of the pulmonary vascular bed in infants exposed in utero to prostaglandin synthesis inhibitors. J Pediatr 1978; 92: 478–83.CrossRefGoogle Scholar
Huhta, JC, Moise, KJ, Fisher, DJ, Sharif, DS, Wasserstrum, N, Martin, C. Detection and quantitation of constriction of the fetal ductus arteriosus by Doppler echocardiography. Circulation 1987; 75: 406–12.CrossRefGoogle ScholarPubMed
Van der Mooren, K, Van Eyck, J, Wladimiroff, JW. Human fetal ductal flow velocity waveforms relative to behavioral states in normal term pregnancy. Am J Obstet Gynecol 1989; 160: 371–74.CrossRefGoogle ScholarPubMed
Van Eyck, J, Stewart, PA, Wladimiroff, JW. Human fetal foramen ovale flow velocity waveforms relative to behavioral states in normal term pregnancy. Am J Obstet Gynecol 1990; in press.CrossRefGoogle ScholarPubMed
Van Eyck, J, Van der Mooren, K, Wladimiroff, JW. Ductus arteriosus flow velocity modulation by fetal breathing movements as a measure of fetal lung development. Am J Obstet Gynecol 1990; in press.CrossRefGoogle ScholarPubMed
Jager, BV, Wollenman, J Jr. Anatomic study of closure of the ductus arteriosus. Am J Pathol 1942; 18: 595–613.Google ScholarPubMed
Gittenberger-de Groot, AC, Strengers, JLM, Mentink, M et al. Histologic studies on normal and persistent ductus arteriosus in the dog. J Am Coll Cardiol 1985; 6: 394–404.CrossRefGoogle ScholarPubMed
Gittenberger-de Groot, AC. Persistent ductus arteriosus: most probably a primary congenital malformation. Br Heart J 1977; 39: 610–18.CrossRefGoogle ScholarPubMed
Moss, AJ, Emmanouilides, GC, Rettori, O et al. Postnatal circulatory and metabolic adjustments in normal and distressed premature infants. Biol Neonate 1966; 8: 177–97.CrossRefGoogle Scholar
Dawes, GS, Mott, JC, Widdicombe, JG. The patency of the ductus arteriosus in newborn lambs and its physiological consequences. J Physiol 1955; 128: 361–83.CrossRefGoogle ScholarPubMed
Rudolph, AM, Scarpelli, EM, Golinko, RJ et al. Hemodynamic basis for clinical manifestations of patent ductus arteriosus. Am Heart J 1964; 68: 447–58.CrossRefGoogle ScholarPubMed
Kennedy, JA, Clark, SL. Observations on the physiological reactions of the ductus arteriosus. Am J Physiol 1942; 136: 140–47.CrossRefGoogle Scholar
Hornblad, PY. Experimental studies on closure of the ductus arteriosus utilizing whole body freezing. Acta Pediatr Scand 1969; 190(suppl): 6–21.Google Scholar
Broccoli, F, Carinci, P. Histological and histochemical analysis of the obliteration processes of ductus arteriosus Botalli. Acta Anat 1973; 85: 69–83.CrossRefGoogle ScholarPubMed
Fay, FS, Cooke, PH. Guinea-pig ductus arteriosus. II. Irreversible closure after birth. Am J Physiol 1972; 222: 841–49.CrossRefGoogle ScholarPubMed
Jones, M, Barrow, MV, Wheat, MW. An ultrastructural evaluation of the closure of the ductus arteriosus in rats. Surgery 1969; 66: 891–98.Google ScholarPubMed
Kennedy, JA, Clark, SL. Observations on the ductus arteriosus of the guinea pig in relation to its method of closure. Anat Rec 1941; 79: 349–52.CrossRefGoogle Scholar
Assali, NS, Morris, JA, Smith, RW, Manson, WA. Studies on the ductus arteriosus circulation. Circ Res 1962; 13: 478–52.CrossRefGoogle Scholar
Rudolph, AM. Fetal and neonatal pulmonary circulation. Annu Rev Physiol 1979; 41: 383–87.CrossRefGoogle ScholarPubMed
Born, GBR, Dawes, GS, Mott, JC, Renninck, BR. The constriction of the ductus arteriosus caused by oxygen and asphyxia in newborn lambs. J Physiol 1956; 132: 304–308.CrossRefGoogle ScholarPubMed
Alzamora-Castro, V, Battilana, G, Abugattas, R et al. Patent ductus arteriosus and high altitude. Am J Cardiol 1960; 5: 761–63.CrossRefGoogle ScholarPubMed
Penaloza, D, Arias-Stella, J, Sime, F et al. The heart and pulmonary circulation in children at high altitudes. Pediatrics 1964; 34: 568–82.CrossRefGoogle ScholarPubMed
Moss, AJ, Emmanouilides, GC, Adams, FH et al. Reponse of ductus arteriosus and pulmonary and systemic arterial pressure to changes in oxygen environment in newborn infants. Pediatrics 1964; 33: 937–44.CrossRefGoogle Scholar
Fay, FS. Guinea pig ductus arteriosus. I. Cellular and metabolic basis for oxygen sensitivity. Am J Physiol 1971; 224: 470–79.CrossRefGoogle Scholar
Fay, FS, Jobsis, FF. Guinea pig ductus arteriosus. III. Light absorption changes during response to O2. Am J Physiol 1972; 223: 588–95.CrossRefGoogle Scholar
Coceani, F, Olley, PM. Control of muscle tone in the ductus arteriosus. In: Longenecker, GL, Schaffer, SW eds, Prostaglandins 1984: research and clinical update. Minneapolis: Burgess, 1985: 97–117.Google Scholar
Coceani, F, Hamilton, NC, Labuc, J et al. Cytochrome P 450-linked monooxygenase: involvement in the lamb ductus arteriosus. Am J Physiol 1984; 246: H640–43.Google ScholarPubMed
Coceani, F, Olley, PM. The control of cardiovascular shunts in the fetal and perinatal period. Can J Physiol Pharmacol 1988; 66: 1129–34.CrossRefGoogle ScholarPubMed
Starling, MB, Elliot, RB. The effects of prostaglandins, prostaglandin inhibitors, and oxygen on the closure of the ductus arteriosus, pulmonary arteries, and umbilical vessels in vitro. Prostaglandins 1974; 8: 187–203.CrossRefGoogle ScholarPubMed
Boreus, IO, Malmfors, T, McMurphy, DM et al. Demonstration of adrenergic reception function and innervation in the ductus arteriosus of the human fetus. Acta Physiol Scand 1969; 77: 316–21.CrossRefGoogle Scholar
Friedman, WF, Printz, MP, Skidgel, RA, Benson, LN, Zednikova, M. Prostaglandins and the ductus arteriosus. In: Oates, JA ed, Prostaglandins and the cardiovascular system, New York: Raven Press, 1982: 277–302.Google Scholar
Powell, WS, Solomon, S. Biosynthesis of prostaglandins and thromboxane B2 by fetal lung homogenates. Prostaglandins 1978; 15: 351–64.CrossRefGoogle ScholarPubMed
Sun, FF, McGuire, JC. Metabolism of prostaglandins and prostaglandin endoperoxides in rabbit tissues during pregnancy: differences in enzyme activities between mother and fetus. In: Coceani, F, Olley, PM eds, Advances in prostaglandin and thromboxane research, Volume 4, New York: Raven Press, 1978: 75–85.Google Scholar
Kovalcik, V. The response of the isolated ductus arteriosus to oxygen and anoxia. J Physiol (Lond) 1963; 169: 185–97.CrossRefGoogle ScholarPubMed
Aronson, SG, Gennser, G, Owman, C et al. Innervation and contractile response of the human ductus arteriosus. Eur J Pharmacol 1970; 11: 178–86.CrossRefGoogle ScholarPubMed
McMurphy, DM, Boreus, L. Studies on the pharmacology of the perfused human fetal ductus arteriosus. Am J Obstet Gynecol 1971; 109: 937–42.CrossRefGoogle ScholarPubMed
McMurphy, DM, Heymann, MA, Rudolph, AM et al. Developmental changes in constriction of the ductus arteriosus: responses to oxygen and vasoactive substances in the isolated ductus arteriosus of the fetal lamb. Pediatr Res 1972; 6: 231–38.CrossRefGoogle Scholar
Smith, RW, Morris, JA, Assali, NS et al. Effects of chemical mediators on the pulmonary and ductus arteriosus circulation in the fetal lamb. Am J Obstet Gynecol 1964; 89: 252–60.CrossRefGoogle ScholarPubMed
Siassi, B, Blanco, C, Cabal, LA et al. Incidence and clinical features of patent ductus arteriosus in low-birth-weight infants: a prospective analysis of 150 consecutively born infants. Pediatrics 1976; 57: 347–51.CrossRefGoogle ScholarPubMed
Kitterman, JA, Edmunds, LH, Gregory, GA et al. Patent ductus arteriosus in premature infants: incidence, relation to pulmonary disease and management. N Engl J Med 1972; 287: 473–7.CrossRefGoogle ScholarPubMed
Thibeault, DW, Emmanouilides, GC, Nelson, RJ et al. Patent ductus arteriosus complicating the respiratory distress syndrome in preterm infants. J Pediatr 1975; 86: 120–26.CrossRefGoogle ScholarPubMed
Thibeault, DW, Emmanouilides, GC, Dodge, ME et al. Early functional closure of the ductus arteriosus associated with decreased severity of respiratory distress syndrome in preterm infants. Am J Dis Child 1977; 131: 741–45.Google ScholarPubMed
Neal, WA, Bessinger, FB, Hunt, CE et al. Patent ductus arteriosus complicating respiratory distress syndrome. J Pediatr 1975; 86: 127–31.CrossRefGoogle ScholarPubMed
Levitsky, S, Fisher, E, Vidyasagar, D et al. Interruption of patent ductus arteriosus in premature infants with respiratory distress. Ann Thorac Surg 1976; 2: 131–37.CrossRefGoogle Scholar
Alzamora, V, Rotta, A, Battilana, G et al. On the possible influence of great altitudes on the determination of certain cardiovascular anomalies. Pediatrics 1953; 12: 259–62.CrossRefGoogle ScholarPubMed
Kitterman, J. Effects of intestinal ischemia. In: Moore, T ed, Necrotizing enterocolitis in the newborn infants: report of the sixty-eighth Ross Conference on Pediatric Research, Columbus: Ross Laboratories, 1975: 38–40.Google Scholar
Lipman, B, Serwer, G, Brazy, JE. Abnormal cerebral hemodynamics in preterm infants with patent ductus arteriosus. Pediatrics 1982; 69: 778.CrossRefGoogle ScholarPubMed
Seyberth, HW, Müller, H, Ulmer, HE, Wille, L. Urinary excretion rates of 6-keto-PGF1α in preterm infants recovering from respiratory distress with and without patent ductus arteriosus. Pediatr Res 1984; 18: 520–24.CrossRefGoogle ScholarPubMed
McCarthy, JS, Zies, LG, Gelband, H. Age dependent closure of the patent ductus arteriosus by indomethacin. Pediatrics 1978; 62: 706–10.CrossRefGoogle ScholarPubMed
Brash, AR, Hickey, DE, Graham, TP et al. Pharmacokinetics of indomethacin in the neonate: relation of plasma indomethacin levels to response of the ductus arteriosus. N Engl J Med 1981; 305: 67–70.CrossRefGoogle ScholarPubMed
Ivey, HH, Kattwinkel, J, Park, TS et al. Failure of indomethacin to close persistent ductus arteriosus in infants weighing under 1000gm. Br Heart J 1979; 41: 304–307.CrossRefGoogle Scholar
Cooke, RWI, Pickering, D. Poor response to oral indomethacin therapy for persistent ductus arteriosus in very low birthweight infants. Br Heart J 1979; 41: 301–304.CrossRefGoogle ScholarPubMed
Alpert, BS, Lewins, MJ, Rowland, DW et al. Plasma indomethacin levels in preterm newborn infants with symptomatic patent ductus arteriosus – clinical and echocardiographic assessments of response. J Pediatr 1979; 95: 578–80.CrossRefGoogle ScholarPubMed
Halliday, HL, Hirata, T, Brady, JP. Indomethacin therapy for large patent ductus arteriosus in the very low birthweight infant: results and complications. Pediatrics 1979; 64: 154–56.CrossRefGoogle Scholar
Kreil, E, Zapol, W, Shorp, G et al. Effects of cyclic AMP on isolated ductus arteriosus. Pediatr Res 1973; 7: 300–304.Google Scholar
Steiner, AL, Parker, CW, Kipnis, DM. Radioimmunoassay for cyclic nucleotides. J Biol Chem 1972; 247: 1106–13.CrossRefGoogle ScholarPubMed
Walsh, RS, Ely, SW, Mentzer, RM Jr. Response of lumb ductus arteriosus to nitroglycerin and nitroprusside. J Surg Res 1988; 44: 8–13.CrossRefGoogle Scholar
Freed, MD, Heymann, MA, Lewis, AB, Roehl, SL, R., Chen Kensey Prostaglandin E1 in infants with ductus arteriosus-dependent congenital heart disease. Circulation 1981; 64: 899–905.CrossRefGoogle ScholarPubMed
Clyman, RI, Ballard, PL, Sniderman, S et al. Prenatal administration of betamethasone for prevention of patent ductus arteriosus. J Pediatr 1981; 98: 123–26.CrossRefGoogle Scholar
Waffran, F, Siassi, B, Cabal, LA, Schmidt, PL. Effect of antenatal glucocorticoids on clincal closure of the ductus arteriosus. Am J Dis Child 1983; 137: 336–40.Google Scholar
Momma, K, Nishihara, S, Ota, Y. Constriction of the fetal ductus arterisosus by glucocorticoid hormones. Pediatr Res 1981; 15: 19–21.CrossRefGoogle ScholarPubMed
Tsai, MY, Brown, DM. Effect of dexamethasone on fetal lung 15-hydroxyprostaglandin dehydrogenase: possible mechanism for the prevention of patent ductus arteriosus by maternal dexamethasone therapy. Prostaglandins Leukotrienes Med 1987; 27: 237–45.CrossRefGoogle ScholarPubMed
Clyman, RI, Mauray, F, Heymann, MA et al. Ductus arteriosus: developmental response to oxygen and indomethacin. Prostaglandins 1978; 15: 993–98.CrossRefGoogle ScholarPubMed
Leffler, CW, Tyler, TL, Cassin, S. Effects of indomethacin on pulmonary vascular response to ventilation of fetal goats. Am J Physiol 1978; 234: H346–51.Google ScholarPubMed
Terragno, NA, Terragno, DA, McGiff, JC. The role of prostaglandins in the control of uterine blood flow. Perspectives in Nephrology and Hypertension 1976; 5: 391–98.Google ScholarPubMed
McLaughlin, MK, Brennan, SC, Chez, RA. Effects of indomethacin on sheep utero-placental circulations and sensitivity to angiotensin II. Am J Obstet Gynecol 1978; 132: 430–35.CrossRefGoogle Scholar
Millard, RW, Baig, H, Vatner, S. Renal vascular protection by prostaglandins during hypoxia in unanesthetized fetal lamb. Pediatr Res 1977; 11: 395.CrossRefGoogle Scholar
Starr, MS. Effects of prostaglandin on blood flow in the rabbit eye. Exp Eye Res 1971; 11: 161–69.CrossRefGoogle ScholarPubMed
Yabek, SM, Avner, BP. Effects of prostaglandin E1 and indomethacin on fetal and neonatal lamb mesenteric artery responses to norepinephrine. Prostaglandins 1979; 17: 227–33.CrossRefGoogle ScholarPubMed
Pickard, JD, MacKenzie, ET. Inhibition of prostaglandin synthesis and the response of baboon cerebral circulation to carbon dioxide. Nature New Biol 1973; 245: 187–88.CrossRefGoogle ScholarPubMed
Kimmel, CA, Wilson, JG, Schumacher, HJ. Studies on metabolism and identification of the causative agent in aspirin teratogenesis in rats. Teratology 1971; 4: 15–24.CrossRefGoogle ScholarPubMed
Kohler, HG. Intrauterine cardiac failure associated with premature close of the ductus arteriosus. Arch Dis Child 1967; 42: 335.Google Scholar
Zuckerman, H, Reiss, U, Rubinstein, I. Inhibition of human premature labor by indomethacin. J Obstet Gynecol 1974; 44: 787–92.Google ScholarPubMed
Wiqvist, N, Lundstrom, V, Green, K. Premature labor and indomethacin. Prostaglandins 1975; 10: 515–26.CrossRefGoogle Scholar
Manchester, D, Margolis, HS, Sheldon, RE. Possible association between maternal indomethacin therapy and primary pulmonary hypertension of the newborn. Am J Obstet Gynecol 1976; 126: 467–69.CrossRefGoogle ScholarPubMed
Reiss, U, Atad, J, Rubinstein, I et al. The effect of indomethacin in labour at term. Int J Gynaecol Obstet 1976; 14: 369–74.CrossRefGoogle ScholarPubMed
Csaba, IF, Sulyok, E, Ertl, T. Relationship of maternal treatment with indomethacin to persistence of fetal circulation syndrome. J Pediatr 1978; 92: 484.CrossRefGoogle ScholarPubMed
Grella, P, Zanor, P. Premature labor and indomethacin. Prostaglandins 1978; 16: 1007–17.CrossRefGoogle ScholarPubMed
Rubaltelli, FF, Chiozza, ML, Zanardo, V et al. Effect on neonate of maternal treatment with indomethacin. J Pediatr 1979; 94: 161.CrossRefGoogle ScholarPubMed
Perkin, RM, Levin, DL, Clark, R. Serum salicylate levels and right to left ductus shunts in infants with persistent pulmonary hypertension of the newborn. J Pediatr 1980; 96: 721–26.CrossRefGoogle Scholar
Kumor, KM, White, RD, Blake, DA et al. Indomethacin as a treatment for premature labor: neonatal outcome. Pediatr Res 1979; 13: 370.Google Scholar
Turner, G, Collins, E. Fetal effects of regular salicylate ingestion in pregnancy. Lancet 1975; 2: 338–39.CrossRefGoogle ScholarPubMed
McNeil, JR. The possible teratogenic effect of salicylates in the developing fetus. Clin Pediatr 1973; 12: 374–50.Google Scholar
Schapiro, S, Monson, RR, Kaufman, DW et al. Perinatal mortality and birth-weight in relation to aspirin taken during pregnancy. Lancet 1976; 1: 1375–76.CrossRefGoogle Scholar
Slone, D, Heinonen, OP, Kaufman, DW et al. Aspirin and congenital malformations. Lancet 1976; 1: 1373–75.CrossRefGoogle ScholarPubMed
Collins, E, Turner, G. Maternal effects of regular salicylate ingestion in pregnancy. Lancet 1975; 2: 335–37.CrossRefGoogle ScholarPubMed