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Role of chemokines in proteinuric kidney disorders

Published online by Cambridge University Press:  17 February 2014

Juan Antonio Moreno
Department of Nephrology, IIS-Fundación Jiménez Díaz, Autonoma University, Madrid, Spain
Sara Moreno
Department of Biotechnology, INIA, Madrid, Spain
Alfonso Rubio-Navarro
Department of Nephrology, IIS-Fundación Jiménez Díaz, Autonoma University, Madrid, Spain
Carmen Gómez-Guerrero
Department of Nephrology, IIS-Fundación Jiménez Díaz, Autonoma University, Madrid, Spain Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Madrid, Spain
Alberto Ortiz
Department of Nephrology, IIS-Fundación Jiménez Díaz, Autonoma University, Madrid, Spain Fundacion Renal Iñigo Alvarez de Toledo/Instituto Reina Sofia de Investigacion Nefrologica (FRIAT/IRSIN), Spain
Jesús Egido
Department of Nephrology, IIS-Fundación Jiménez Díaz, Autonoma University, Madrid, Spain Fundacion Renal Iñigo Alvarez de Toledo/Instituto Reina Sofia de Investigacion Nefrologica (FRIAT/IRSIN), Spain Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Madrid, Spain
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Experimental and human studies have shown that proteinuria contributes to the progression of renal disease. Overexposure to filtered proteins promotes the expression and release of chemokines by tubular epithelial cells, thus leading to inflammatory cell recruitment and renal impairment. This review focuses on recent progress in cellular and molecular understanding of the role of chemokines in the pathogenesis of proteinuria-induced renal injury, as well as their clinical implications and therapeutic potential.

Review Article
Copyright © Cambridge University Press 2014 

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Role of chemokines in proteinuric kidney disorders
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