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Impact of miRNAs in gastrointestinal cancer diagnosis and prognosis

Published online by Cambridge University Press:  14 October 2010

Bo Song
Affiliation:
Translational Research Laboratory, Department of Pathology, State University of New York at Stony Brook, Stony Brook, NY, USA.
Jingfang Ju*
Affiliation:
Translational Research Laboratory, Department of Pathology, State University of New York at Stony Brook, Stony Brook, NY, USA.
*
*Corresponding author: Jingfang Ju, Translational Research Laboratory, BST L9, Room 185, Department of Pathology, Stony Brook University Medical Center, Stony Brook, NY 11794-8691, USA. E-mail: jiju@notes.cc.sunysb.edu

Abstract

Since the discovery of noncoding small RNAs such as microRNAs (miRNAs), and their roles as potential tumour suppressors or oncogenes, post-transcriptional and translational control of gene expression have become increasingly important in cancer research. Given that over a third of coding genes, as estimated by computational prediction, are regulated by miRNAs, various types of cancer will show direct association with changes in miRNA expression. The link of certain miRNAs with specific developmental stages, tissues and cancer contributes to their strong potential as biomarkers and novel therapeutic targets. In this review, we cover recent advances in miRNA research in human gastrointestinal cancer (colorectal, gastric, pancreatic and liver) and the potential of miRNAs as diagnostic and prognostic biomarkers.

Type
Review Article
Copyright
Copyright © Cambridge University Press 2010

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References

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Further reading, resources and contacts

Lee, R.C., Feinbaum, R.L. and Ambros, V. (1993) The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 75, 843-854Google Scholar
Fire, A. et al. (1998) Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391, 806-811Google Scholar
Calin, G.A. et al. (2002) Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proceedings of the National Academy of Sciences of the United States of America 99, 15524-15529Google Scholar
Bartel, D.P. (2004) MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116, 281-297Google Scholar
Xi, Y. et al. (2006) Differentially regulated micro-RNAs and actively translated messenger RNA transcripts by tumor suppressor p53 in colon cancer. Clinical Cancer Research 12, 2014-2024Google Scholar