Immune defence mechanisms and immunoenhancement strategies in oropharyngeal candidiasis

Cristina Cunha Villar; Anna Dongari-Bagtzoglou

doi:10.1017/S1462399408000835

Immune defence mechanisms and immunoenhancement strategies in oropharyngeal candidiasis

Published online by Cambridge University Press: 13 October 2008

Cristina Cunha Villar and

Anna Dongari-Bagtzoglou

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Cristina Cunha Villar*: Affiliation:
Department of Periodontics, University of Texas Health Science Center at San Antonio School of Dentistry, San Antonio, Texas, USA.
Anna Dongari-Bagtzoglou: Affiliation:
Division of Periodontology, School of Dental Medicine, University of Connecticut, Farmington, USA.
*: *Corresponding author: Cristina Cunha Villar, Department of Periodontics, University of Texas Health Science Center at San Antonio, School of Dentistry, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA. Tel: +1 210 567 3600; Fax: +1 210 567 6858; E-mail: villar@uthscsa.edu

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Abstract

The prevalence of oropharyngeal candidiasis continues to be high, mainly because of an increasing population of immunocompromised patients. Traditional treatment of oropharyngeal candidiasis has relied on the use of antimicrobial drugs. However, unsatisfactory results with drug monotherapy and the emergence of resistant strains have prompted investigations into the potential use of adjunctive immunoenhancing therapies for the treatment of these infections. Here we review the host-recognition systems of Candida albicans, the immune and inflammatory response to infection, and antifungal effector mechanisms. The potential of immune modulation as a therapeutic strategy in oropharyngeal candidiasis is also discussed.

Type: Review Article
Information: Expert Reviews in Molecular Medicine , Volume 10 , October 2008 , e29

DOI: https://doi.org/10.1017/S1462399408000835 [Opens in a new window]
Copyright: Copyright © Cambridge University Press 2008

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Immune defence mechanisms and immunoenhancement strategies in oropharyngeal candidiasis

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Article contents

Immune defence mechanisms and immunoenhancement strategies in oropharyngeal candidiasis

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