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Designer functionalised self-assembling peptide nanofibre scaffolds for cartilage tissue engineering

Published online by Cambridge University Press:  04 August 2014

Bin He ,
Xiao Yuan ,
Aiguo Zhou ,
Hua Zhang  and
Dianming Jiang
Bin He
Affiliation:
Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
Xiao Yuan
Affiliation:
Department of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
Aiguo Zhou
Affiliation:
Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
Hua Zhang
Affiliation:
Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
Dianming Jiang*
Affiliation:
Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
*
*Corresponding author:D. Jiang, No. 1 Yi Xue Yuan Road, Yuzhong District, Chongqing, 400016, China. Tel: 008689011212; Fax: 008689011212; E-mail: jdm571026@vip.163.com
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Abstract

Owing to the limited regenerative capacity of cartilage tissue, cartilage repair remains a challenge in clinical treatment. Tissue engineering has emerged as a promising and important approach to repair cartilage defects. It is well known that material scaffolds are regarded as a fundamental element of tissue engineering. Novel biomaterial scaffolds formed by self-assembling peptides consist of nanofibre networks highly resembling natural extracellular matrices, and their fabrication is based on the principle of molecular self-assembly. Indeed, peptide nanofibre scaffolds have obtained much progress in repairing various damaged tissues (e.g. cartilage, bone, nerve, heart and blood vessel). This review outlines the rational design of peptide nanofibre scaffolds and their potential in cartilage tissue engineering.

Type
Review Article
Information
Expert Reviews in Molecular Medicine , Volume 16 , 2014 , e12
Copyright
Copyright © Cambridge University Press 2014 

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