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Response of isolated ruminant mammary arteries to the long R3 analogue of insulin-like growth factor I

Published online by Cambridge University Press:  25 January 2001

I. F. Gow
I. F. Gow
Affiliation:
Integrative Metabolism Group, Hannah Research Institute, Ayr KA6 5HL, UK
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Abstract

Isolated mammary arteries from ruminants were used in a conventional organ bath system. Acetylcholine relaxed bovine but not ovine mammary arteries; both types responded to sodium nitroprusside. Noradrenaline (NA) caused a dose-dependent increase in generated tension. An analogue of insulin-like growth factor I (long R3-IGF-I) caused a rightward shift in the NA response curve in bovine vessels with intact endothelium (P < 0.02), and also in sheep arteries (P < 0.01). In bovine vessels, this effect was abolished when the endothelium was removed. The effect of long R3-IGF-I in bovine vessels was abolished by N ω-nitro-L-arginine methyl ester (L-NAME) an inhibitor of nitric oxide synthase, suggesting the effect of IGF-I on mammary arteries in vitro requires NO generation. Experimental Physiology (2000) 85.3, 275-279.

Type
Research Article
Information
Experimental Physiology , Volume 85 , Issue 3 , May 2000 , pp. 275 - 279
Copyright
© The Physiological Society 2000

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