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Live now - pay by ageing: high performance mitochondrial activity in youth and its age-related side effects

Published online by Cambridge University Press:  09 January 2003

G. Hofhaus ,
M. Berneburg ,
M. Wulfert  and
N. Gattermann
G. Hofhaus
Affiliation:
Institut für Biochemie Geb 26.42/03, Heinrich-Heine-Universität Düsseldorf, Universitätstraße 1, D-40225 Düsseldorf, Molekulare Onkologie und Alterung, Hautklinik, Universitätsklinikum Düsseldorf and Klinik für Hämatologie, Onkologie und klinische Immunologie, Universitätsklinikum Düsseldorf, Germany
M. Berneburg
Affiliation:
Institut für Biochemie Geb 26.42/03, Heinrich-Heine-Universität Düsseldorf, Universitätstraße 1, D-40225 Düsseldorf, Molekulare Onkologie und Alterung, Hautklinik, Universitätsklinikum Düsseldorf and Klinik für Hämatologie, Onkologie und klinische Immunologie, Universitätsklinikum Düsseldorf, Germany
M. Wulfert
Affiliation:
Institut für Biochemie Geb 26.42/03, Heinrich-Heine-Universität Düsseldorf, Universitätstraße 1, D-40225 Düsseldorf, Molekulare Onkologie und Alterung, Hautklinik, Universitätsklinikum Düsseldorf and Klinik für Hämatologie, Onkologie und klinische Immunologie, Universitätsklinikum Düsseldorf, Germany
N. Gattermann
Affiliation:
Institut für Biochemie Geb 26.42/03, Heinrich-Heine-Universität Düsseldorf, Universitätstraße 1, D-40225 Düsseldorf, Molekulare Onkologie und Alterung, Hautklinik, Universitätsklinikum Düsseldorf and Klinik für Hämatologie, Onkologie und klinische Immunologie, Universitätsklinikum Düsseldorf, Germany
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Abstract

Radical oxygen species are a byproduct of normal energy metabolism in mitochondria. The short-lived radicals cause damage to their immediate surrounding, i.e. the mitochondria. While most of this damage will be removed by normal mitochondrial turnover, damage to mitochondrial DNA (mtDNA) can persist and may accumulate with age. Recent evidence indicates that mutant mtDNA molecules can accumulate within individual cells, potentially hampering mitochondrial function. Experimental Physiology (2003) 88.1, 167-174.

Type
Special Review Series - Biogenesis and Physiological Adaptation of Mitochondria
Information
Experimental Physiology , Volume 88 , Issue 1 , January 2003 , pp. 167 - 174
Copyright
© The Physiological Society 2003

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