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Study of Dat 10/10 in Family Cohort

Published online by Cambridge University Press:  15 April 2020

I. Paclt ,
N. Pribilova ,
P. Kollarova ,
T. Calkova ,
M. Dezortova  and
M. Hajek
I. Paclt
Affiliation:
Psychiatry, First Faculty of Medicine Charles University, Prague 2, Czech Republic
N. Pribilova
Affiliation:
Psychiatry, First Faculty of Medicine Charles University, Prague 2, Czech Republic
P. Kollarova
Affiliation:
Psychiatry, First Faculty of Medicine Charles University, Prague 2, Czech Republic
T. Calkova
Affiliation:
Psychiatry, First Faculty of Medicine Charles University, Prague 2, Czech Republic
M. Dezortova
Affiliation:
Department of computed tomography magnetic resonance imaging and clinical and experimental spectroscopy, Institute for Clinical and Experimental Medicine, Prague 4, Czech Republic
M. Hajek
Affiliation:
Department of computed tomography magnetic resonance imaging and clinical and experimental spectroscopy, Institute for Clinical and Experimental Medicine, Prague 4, Czech Republic

Abstract

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<p style="text-align: left;">The dopamine transporter (DAT) is a functional element of the dopaminergic synapse in the brain. Its primary role is the regulation of dopamine (DA) availability. The DAT gene and especially the DAT 10/10 genotype have been intensively discussed as a candidate for several neuropsychiatric disorders including attention-deficit-hypractivity disorder (ADHD).

<p style="text-align: left;">Our previous research suggests theassociation of genes DRD2, DAT1, DBH and 5-HTT with ADHD

<p style="text-align: left;">(P<0,05) – case control study. DAT1 corelates with ADHD in our family based study (P<0,05).

<p style="text-align: left;">Data from current family-basedstudy denoted that tranmission of polymorphisms in the genes DRD3 (allele 2),5-HTT (VNTR), DBH 444A and DRD4 −512 is exclusively from father to son. In caseof mothers, maternally transmission of ADHD is more or less insignificant.

<p style="text-align: left;">50 ADHD pactients from family based study presented polymorfism 10/10. We present new data of neuro imaging (nucleus cadatus, nucleus lentiformis) and some psychological scales in these goups compare to norm healthy controls of same age.

This research wasfinancially supported by a grant NT14177.

Type
Article: 1179
Information
European Psychiatry , Volume 30 , Issue S1: Abstracts of the 23rd European Congress of Psychiatry , March 2015 , pp. 1
Copyright
Copyright © European Psychiatric Association 2015
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