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S39-02 - Timing is Critical: Gene, Environment and Timing Interactions in Genetics of Suicide in Children and Adolescents

Published online by Cambridge University Press:  17 April 2020

G. Zalsman*
Affiliation:
Child and Adolescent Division, The Geha Mental Health Center, Petach Tikva, Israel Tel Aviv University, Tel Aviv, Israel

Abstract

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Suicidal behavior runs in families and is prevalent in adolescence. Case-control and family-based studies in this age group failed to find a genetic association that survived replications. Gene-environment approach gave new hope for possible associations especially with the short allele of the serotonin transporter promoter polymorphism (5HTTLPR). However, a recent meta-analysis raised doubts about the consistency of these findings. Some new structural and functional imaging data may shade light on the age-related and gender-related development of the brain. This review suggests a new approach to Gene-by-Environment and timing interaction to understand the interplay that leads to suicidality in adolescents and young adults.

Type
Risk behavior and self mutilation in adolescents: problem of nature or nurture?
Copyright
Copyright © European Psychiatric Association 2010
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