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The role of high-density lipoprotein cholesterol in risk for posttraumatic stress disorder: Taking a nutritional approach toward universal prevention

Published online by Cambridge University Press:  15 April 2020

K. Hamazaki ,
D. Nishi ,
N. Yonemoto ,
H. Noguchi ,
Y. Kim  and
Y. Matsuoka
K. Hamazaki
Affiliation:
Department of Clinical Epidemiology, Translational Medical Center, National Center of Neurology and Psychiatry, Tokyo, Japan Department of Public Health, Faculty of Medicine, University of Toyama, Toyama, Japan CREST, Japan Science and Technology Agency, Tokyo, Japan
D. Nishi
Affiliation:
National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan Department of Psychiatry, National Disaster Medical Center, Tokyo, Japan CREST, Japan Science and Technology Agency, Tokyo, Japan
N. Yonemoto
Affiliation:
Department of Clinical Epidemiology, Translational Medical Center, National Center of Neurology and Psychiatry, Tokyo, Japan National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan CREST, Japan Science and Technology Agency, Tokyo, Japan
H. Noguchi
Affiliation:
Department of Clinical Epidemiology, Translational Medical Center, National Center of Neurology and Psychiatry, Tokyo, Japan CREST, Japan Science and Technology Agency, Tokyo, Japan
Y. Kim
Affiliation:
National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan
Y. Matsuoka*
Affiliation:
Department of Clinical Epidemiology, Translational Medical Center, National Center of Neurology and Psychiatry, Tokyo, Japan National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan Department of Psychiatry, National Disaster Medical Center, Tokyo, Japan CREST, Japan Science and Technology Agency, Tokyo, Japan
*
*Corresponding author at: Department of Clinical Epidemiology, Translational Medical Center, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi-cho, Kodaira, Tokyo 187-8551, Japan. E-mail address: yutaka@ncnp.go.jp (Y. Matsuoka).
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Abstract

Several cross-sectional studies, but no prospective studies, have reported an association between an abnormal lipid profile and posttraumatic stress disorder (PTSD). We hypothesized that an abnormal lipid profile might predict risk for developing PTSD. In this prospective study, we analyzed data from 237 antidepressant-naïve severely injured patients who participated in the Tachikawa Cohort of Motor Vehicle Accident Study. High-density lipoprotein cholesterol (HDL-C) levels at baseline were significantly lower in patients with PTSD than those without PTSD at 6 months after motor vehicle accident (MVA) and were inversely associated with risk for PTSD. In contrast, triglycerides (TG) at baseline were significantly higher in patients with PTSD than in those without PTSD at 6 months post-MVA and were positively associated with risk for PTSD. There was no clear association between low-density lipoprotein cholesterol or total cholesterol and risk for PTSD. In conclusion, low HDL-C and high TG may be risk factors for PTSD. Determining lipid profiles might help identify those at risk for PTSD after experiencing trauma.

Keywords

Posttraumatic stress disorderEpidemiology ;Lipid profile
Type
Original article
Information
European Psychiatry , Volume 29 , Issue 7 , September 2014 , pp. 408 - 413
Copyright
Copyright © 2014 Elsevier Masson SAS

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