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Prolactin responses to im haloperidol in drug-naive and drug-experienced schizophrenic patients

Published online by Cambridge University Press:  16 April 2020

M Markianos ,
A Botsis ,
J Hatzimanolis  and
C Stefanis
M Markianos
Affiliation:
Athens University Medical School, Psychiatric Clinic, Eginition Hospital and University Research Institute for Mental Health, Vas Sophias 74, 11528Athens, Greece
A Botsis
Affiliation:
Athens University Medical School, Psychiatric Clinic, Eginition Hospital and University Research Institute for Mental Health, Vas Sophias 74, 11528Athens, Greece
J Hatzimanolis
Affiliation:
Athens University Medical School, Psychiatric Clinic, Eginition Hospital and University Research Institute for Mental Health, Vas Sophias 74, 11528Athens, Greece
C Stefanis
Affiliation:
Athens University Medical School, Psychiatric Clinic, Eginition Hospital and University Research Institute for Mental Health, Vas Sophias 74, 11528Athens, Greece
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Summary

The prolactin (PRL) responses to 5 mg im haloperidol were assessed in the drug-free state and after one month treatment with neuroleptics in 14 male schizophrenic patients who had never received drug treatment, and in 20 male patients who had discontinued their neuroleptic treatment for periods of two months to one year. Drug experienced patients showed lower PRL increases after acute haloperidol (mean 31.7 ng/ml) than drug-naive patients (mean responses 43.4 ng/ml). After treatment with neuroleptics in doses appropriate for the best clinical response, the baseline PRL levels were similar in the two groups, and im haloperidol did not cause any further PRL increases. The results provide evidence that after discontinuation of neuroleptics, the hypothalamic-pituitary dopamine receptors are subsensitive, and remain in that state for long periods of time.

Keywords

schizophreniadrug naive patientshaloperidolprolactin
Type
Original article
Information
European Psychiatry , Volume 9 , Issue 2 , 1994 , pp. 91 - 94
Copyright
Copyright © European Psychiatric Association 1994

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