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Postoperative psychosis in homocystinuria

Published online by Cambridge University Press:  16 April 2020

GW Eschweiler ,
R Rosin ,
P Thier  and
H Giedke
GW Eschweiler
Affiliation:
Universitätsklinik für Psychiatric und Psychotherapie
R Rosin
Affiliation:
Neurologische Universitätsklinik Tübingen, Osianderstrasse 24,72076Tübingen, Germany
P Thier
Affiliation:
Neurologische Universitätsklinik Tübingen, Osianderstrasse 24,72076Tübingen, Germany
H Giedke
Affiliation:
Universitätsklinik für Psychiatric und Psychotherapie
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Summary

Young homocystinuria patients suffering from lens dislocation frequently have to undergo eye surgery. We describe a 16-year-old girl with mild mental retardation who became psychotic-delirant immediately after the last of three lentectomia operations performed under general thiopental anaesthesia. Because methionine, homocysteine, its oxidation product homocysteate and cysteine are potent glutamate agonists, the disturbance of the sulphur containing amino acid (SCAA) metabolism in homocystinuria patients may alter the function of cerebral glutamatergic transmission. The chronic and acute neurological and psychiatric symptoms of homocystinuria patients offer a clue to studies of the neurotoxic but also antipsychotic potency of glutamate agonists like the SCAAs in humans.

Keywords

homocystinuriapsychotic-delirant syndromeglutamatesulphur containing amino acids
Type
Case report
Information
European Psychiatry , Volume 12 , Issue 2 , 1997 , pp. 98 - 101
Copyright
Copyright © Elsevier, Paris 1997

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