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P-542 - Insulin-like Growth Factor 1 Receptor Gene Expression in Patients With Subsyndromal Symptomatic Depression

  • Z. Yi (a1), Z. Li (a1), C. Zhang (a1), W. Hong (a1), C. Yuan (a1), Z. Wu (a1), S. Yu (a1) and Y. Fang (a1)...

Abstract

Objective:

To study the relationship between insulin-like growth factor 1 receptor (IGF1R)and subsyndromal symptomatic depression (SSD).

Methods:

In this case-control study, real-time quantitative reverse transcriptase polymerase chain reaction (RT-qPCR) with TaqMan MGB was used to analyzing the differences of IGF1R gene mRNA expression in peripheral leukocytes between subsyndromal symptomatic depression group(n = 47) and healthy controls(n = 52). At the same time Hamilton Depression Rating Scale -17(HAMD17) were assessed.

Results:

IGF1R gene mRNA expression was 0.21 ± 0.11 in SSD group, 0.56 ± 0.37 in healthy group, and there was significant difference between both groups on IGF1R expression(z = 39.54, P < 0.001). the expression levels of IGF1R in SSD patients was not correlated with Hamilton score(r = −0.292, p = 0.275).

Conclusion:

This study suggested that the decreased expression of IGF1R were related with the pathophysiology of SSD.

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P-542 - Insulin-like Growth Factor 1 Receptor Gene Expression in Patients With Subsyndromal Symptomatic Depression

  • Z. Yi (a1), Z. Li (a1), C. Zhang (a1), W. Hong (a1), C. Yuan (a1), Z. Wu (a1), S. Yu (a1) and Y. Fang (a1)...

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P-542 - Insulin-like Growth Factor 1 Receptor Gene Expression in Patients With Subsyndromal Symptomatic Depression

  • Z. Yi (a1), Z. Li (a1), C. Zhang (a1), W. Hong (a1), C. Yuan (a1), Z. Wu (a1), S. Yu (a1) and Y. Fang (a1)...
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