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P-506 - 12 Weeks of Moderate Intensity Exercise Improves Treatment-resistant Major Depressive Disorder (mdd). Daily use of Accelerometers Contributes to 97% Adherence

Published online by Cambridge University Press:  15 April 2020

J. Mota-Pereira ,
J.C. Ribeiro ,
D. Fonte ,
S. Carvalho ,
A. Pizarro ,
J. Teixeira ,
J. Ramos  and
J. Silverio
J. Mota-Pereira
Affiliation:
Porto Psychiatric Department, Hospital Magalhaes Lemos, Portugal School of Psychology, University of Minho, Portugal
J.C. Ribeiro
Affiliation:
Research Center in Physical Activity Health and Leisure, Faculty of Sports, University of Porto, Portugal
D. Fonte
Affiliation:
Radiotherapy Department, Hospital S. Joao, Portugal
S. Carvalho
Affiliation:
Porto Psychiatric Department, Hospital Magalhaes Lemos, Portugal
A. Pizarro
Affiliation:
Research Center in Physical Activity Health and Leisure, Faculty of Sports, University of Porto, Portugal
J. Teixeira
Affiliation:
Research Center in Physical Activity Health and Leisure, Faculty of Sports, University of Porto, Portugal
J. Ramos
Affiliation:
Psychosocial Rehabilitation Department, Hospital Magalhaes Lemos, Porto, Portugal
J. Silverio
Affiliation:
School of Psychology, University of Minho, Portugal

Abstract

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Introduction:

Physical exercise has shown promising results as an adjuvant therapy for depression. However, most studies rely on self-reported measures, which are subject to bias.

Aims:

To assess, using accelerometer data, compliance to a moderate intensity 12 week exercise program, exercise patterns and relationship between exercise dose and response to treatment, in a population sample of patients with treatment-resistant MDD.

Methods:

Study design Prospective, randomized, two-arm, parallel assignment. Population 150 individuals diagnosed with treatment-resistant MDD were initially screened. Those meeting study criteria were randomized to one of two groups: control (N = 11) and aerobic exercise (N = 22). All participants maintained their usual pharmacotherapy. Study protocol Exercise group: moderate intensity exercise program for 12 weeks. Control group: regular daily activities. All participants wore an ActiGraph® GT1M LLC accelerometer during the 12 weeks. Assessed parameters Moderate plus vigorous physical activity (MVPA), HAMD17, BDI, GAF, CGI-S.

Results:

The exercise group showed better depression and functional parameters at the end of the study compared to the control group (lower HAMD17, BDI, CGI-S; higher GAF, p < 0.05). Compliance was 97% based on accelerometer data and 91% based on self-reports. Participants showed preference for exercising on weekdays and on specific periods of the day.

Although not statistically significant, there was a trend for increasing MVPA from no response to response and remission. MVPA showed significant favourable correlations with all depression and functioning parameters.

Conclusions:

Future implementation of effective exercise augmentation therapy programs should consider exercise dose and objective measures that will allow the quantification of that dose.

Type
Abstract
Information
European Psychiatry , Volume 27 , Issue S1: Abstracts of the 20th European Congress of Psychiatry , 2012 , pp. 1
Copyright
Copyright © European Psychiatric Association 2012
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