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P-1015 - Persistence of Positive Symptoms in Patients at High Risk of Developing a Psychosis

Published online by Cambridge University Press:  15 April 2020

M. Bodatsch ,
F. Schultze-Lutter ,
R.K.R. Salokangas ,
D. Linszen ,
M. Birchwood ,
G. Juckel ,
S. Lewis ,
J. Klosterkotter ,
S. Ruhrmann  and
European Prediction of Psychosis Study (EPOS) Group
M. Bodatsch
Affiliation:
Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany
F. Schultze-Lutter
Affiliation:
Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany University Hospital of Child and Adolescent Psychiatry, University of Bern, Bern, Switzerland
R.K.R. Salokangas
Affiliation:
Turku University Central Hospital, Turku University, Turku, Finland
D. Linszen
Affiliation:
Department of Psychiatry, Academic Medical Centre, Amsterdam, The Netherlands Maastricht University Medical Centre, University of Maastricht, Maastricht, The Netherlands
M. Birchwood
Affiliation:
School of Psychology, University of Birmingham, Birmingham, UK
G. Juckel
Affiliation:
Dept. of Psychiatry and Psychotherapy, Ruhr University Bochum, Bochum, Germany
S. Lewis
Affiliation:
School of Medicine, The University of Manchester, Manchester, UK
J. Klosterkotter
Affiliation:
Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany
S. Ruhrmann
Affiliation:
Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany

Abstract

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Introduction

A considerable part of clinical high-risk samples does not convert to psychosis within the studies' limited observation periods. A part of these ‘non-converters’ shows a remission of symptoms (with unknown future course). Another part, however, maintains the risk state during follow-up.

Objectives

Persistence of indicators for an increased risk of psychosis.

Aims

To investigate, if persistence of attenuated (APS) or brief limited intermittent psychotic symptoms (BLIPS), the core syndromes of ultra-high risk (UHR) criteria, can be predicted clinically.

Methods

N = 129 participants of the European Prediction of Psychosis (EPOS) Study were included into the current analysis. Persistent Risk Symptoms (pRS) were defined as an at-least ‘moderate’ level (SIPS) of at least one positive symptom at all visits (symptom had to remain the same). Functional significance was defined by a GAF-M score ≤60 at 18-month follow-up (T2).

Results

23.3% displayed persistent risk symptoms throughout follow-up. Most frequent pRS were ‘unusual thought contents’, ‘ideas of persecution’ and ‘perceptual disturbances’. In 90% of the pRS subjects, but only in 25.3% of the non-pRS subjects, GAF scores at T2 were below 60 points (p < 0.01).

Logistic regression analysis revealed that the presence of the pRS syndrome at T2 was predictable by the early course of attenuated positive symptoms with maximum accuracy when the number of at least ‘moderate’ symptoms was considered.

Conclusions

A considerable number of subjects at risk showed persistent attenuated positive symptoms associated with long-lasting functional impairments, irrespective of conversion within the foreseeable future.

Type
Abstract
Information
European Psychiatry , Volume 27 , Issue S1: Abstracts of the 20th European Congress of Psychiatry , 2012 , pp. 1
Copyright
Copyright © European Psychiatric Association 2012
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