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Oxidative Stress in Egyptian Children with Autism: Relation to Autoimmunity

Published online by Cambridge University Press:  15 April 2020

D. Hewedi ,
G. Mostafa  and
E.M.A.N. El Hadidi
D. Hewedi
Affiliation:
Department of Psychiatry – Faculty of Medicine – Ain Shams University, Institute of Psychiatry, Cairo, Egypt
G. Mostafa
Affiliation:
Department of Pediatrics – Faculty of Medicine – Ain Shams University, Clinic of Psychiatry, Cairo, Egypt
E.M.A.N. El Hadidi
Affiliation:
Department of Clinical Pathology – Faculty of Medicine – Ain Shams University, Immunology Laboratory, Cairo, Egypt

Abstract

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Introduction

Oxidative stress has been implicated in the pathogenesis of major psychiatric disorders, as the brain has comparatively greater vulnerability to oxidative damage

Objectives and Aims

We are the first to study the relationship between oxidative stress (by measuring plasma F2-isoprostane, as a marker of lipid peroxidation, and glutathione peroxidase, as an antioxidant enzyme) and autoimmunity (as indicated by serum antineuronal antibodies).

Methods

We studied these markers in a group of 44 Egyptian autistic children and 44 healthy matched-children.

Results

Our results showed that oxidative stress was found in 88.64% of autistic children. Oxidative stress, resulting from elevated plasma F2-isoprostane and/or reduced glutathione peroxidase, had significant risk for antineuronal positivity, which was found in 54.5% of autistic children, (odds ratio: 12.38 and 6.43, respectively, confidence interval: 1.37–112.10 and 1.21–34.19, respectively).

Conclusions

the strong association between oxidative stress and autoimmunity in autistic children may indicate the possible role of oxidative stress, through induction of autoimmunity, in some autistic patients. Therefore, studies considering the role of antioxidants and immunotherapy in amelioration of autistic manifestations are recommended.

Type
Article: 0807
Information
European Psychiatry , Volume 30 , Issue S1: Abstracts of the 23rd European Congress of Psychiatry , March 2015 , pp. 1
Copyright
Copyright © European Psychiatric Association 2015
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