Skip to main content Accessibility help
×
Home

O-65 - Effect of Brain-derived Neurotrophic Factor (bdnf) Val66met Polymorphism on Early Onset Schizophrenia in Chinese han Population

  • Z. Yi (a1) (a2), C. Zhang (a1), Z. Wu (a1), W. Hong (a1), Z. Li (a1), S. Yu (a1) and Y. Fang (a1)...

Abstract

Schizophrenia is a chronic psychiatry disorder with high heritability. Schizophrenic patients with early age at onset trend to have more genetic component and thus may be an attractive subpopulation for genetic studies. Brain-derived neurotrophimc factor (BDNF) is considered as candidate gene for schizophrenia. A single nucleotide polymorphism (BDNF Val66Met) was reported to be associated with schizophrenia, although discrepancy remains. The aim of this study was to evaluate the association between BDNF Val66Met polymorphism and schizophrenia using an early onset sample in Chinese Han population. Our sample consisted of 353 schizophrenic patients with onset before age 18 and 394 healthy age and sex matched controls. All subjects were ethnically homogenous Han Chinese origin. No significant differences of genotype or allele distribution were identified between the patients and controls. However, the Met allele was significantly associated with an earlier age at onset in male schizophrenic patients (Kaplan-Meier log-rank test P = 0.005), but not in females (P = 0.289). The BDNF Val66Met polymorphism has an important effect on the age at onset of schizophrenia in a gender-specific manner, and this may provided a significant genetic clue for the etiology of schizophrenia. Therefore, further studies are required to uncover the exact role of BDNF in the development of schizophrenia.

    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      O-65 - Effect of Brain-derived Neurotrophic Factor (bdnf) Val66met Polymorphism on Early Onset Schizophrenia in Chinese han Population
      Available formats
      ×

      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      O-65 - Effect of Brain-derived Neurotrophic Factor (bdnf) Val66met Polymorphism on Early Onset Schizophrenia in Chinese han Population
      Available formats
      ×

      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      O-65 - Effect of Brain-derived Neurotrophic Factor (bdnf) Val66met Polymorphism on Early Onset Schizophrenia in Chinese han Population
      Available formats
      ×

Copyright

O-65 - Effect of Brain-derived Neurotrophic Factor (bdnf) Val66met Polymorphism on Early Onset Schizophrenia in Chinese han Population

  • Z. Yi (a1) (a2), C. Zhang (a1), Z. Wu (a1), W. Hong (a1), Z. Li (a1), S. Yu (a1) and Y. Fang (a1)...

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed.

O-65 - Effect of Brain-derived Neurotrophic Factor (bdnf) Val66met Polymorphism on Early Onset Schizophrenia in Chinese han Population

  • Z. Yi (a1) (a2), C. Zhang (a1), Z. Wu (a1), W. Hong (a1), Z. Li (a1), S. Yu (a1) and Y. Fang (a1)...
Submit a response

Comments

No Comments have been published for this article.

×

Reply to: Submit a response


Your details


Conflicting interests

Do you have any conflicting interests? *