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Maternal obstetric complications and intellectual functioning in patients with schizophrenia and their healthy siblings

Published online by Cambridge University Press:  23 March 2020

H. Karakula-Juchnowicz ,
D. Juchnowicz ,
P. Krukow ,
J. Morylowska-Topolska ,
J. Pawezka ,
M. Flis ,
R. Markiewicz  and
A. Urbanska
H. Karakula-Juchnowicz*
Affiliation:
Medical University of Lublin, Department of Clinical Neuropsychiatry I Department of Psychiatry Psychotherapy and Early Intervention, Lublin, Poland
D. Juchnowicz
Affiliation:
University of Pedagogy of Bialystok, Department of Psychology, Białystok, Poland
P. Krukow
Affiliation:
Medical University of Lublin, Department of Clinical Neuropsychiatry, Lublin, Poland
J. Morylowska-Topolska
Affiliation:
Medical University of Lublin, Department of Clinical Neuropsychiatry, Lublin, Poland
J. Pawezka
Affiliation:
Medical University of Lublin, II Department of Psychiatry and Psychiatric Rehabilitation, Lublin, Poland
M. Flis
Affiliation:
Medical University of Lublin, I Department of Psychiatry Psychotherapy and Early Intervention, Lublin, Poland
R. Markiewicz
Affiliation:
Medical University of Lublin, Department of Psychiatric Nursing Faculty of Nursing and Health Sciences, Lublin, Poland
A. Urbanska
Affiliation:
Medical University of Lublin, II Department of Psychiatry and Psychiatric Rehabilitation, Lublin, Poland
*
* Corresponding author.

Abstract

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Objectives

Intellectual functioning in schizophrenia has been associated with genetic vulnerability and obstetric complications.

Aims

The aim of this study was to assess:

– the incidence of complications during pregnancy, labor and delivery;

– the association of OCs with general intellectual ability in two groups: patients with schizophrenia and their healthy siblings.

Methods

Forty-two patients with schizophrenia according to DSM-IV and 43 their healthy siblings were included in the study and examined using MINI and WAIS-R. Their mothers were interviewed to gather data on OCs. The ‘midwife protocol’ of Parnas et al. was used to quantify the presence and entity of OCs.

Results

Asphyxia, mother's serious illness during pregnancy, premature delivery with weight < 2500 g, labor time > 48 h, infarcts in the placenta and eclampsia were statistically more frequent in schizophrenic group. OCs were more common in individuals with a family history. The two investigated groups were different in the following WAIS-R subtests: comprehension (P = 0.018), block design (P = 0.0001), digit symbol (P = 0.001), as well as in performance IQ and total IQ. In the patient group, correlations between OCs indexes and WAIS-R results include all intelligence quotients (verbal, performance, total IQ) and 5 WAIS-R subtests, while in the sibling group: verbal and total IQ and 2 subtests. The correlation between Vocabulary subtest and OCs was the strongest in both groups.

Conclusion

OCs may interact with genetic vulnerability to increase the risk of schizophrenia and have been associated with cognitive deficits in the patient group.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
FC76
Information
European Psychiatry , Volume 33 , Issue S1: Abstracts of the 24th European Congress of Psychiatry , March 2016 , pp. S102
Copyright
Copyright © European Psychiatric Association 2016
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