Hostname: page-component-7c8c6479df-r7xzm Total loading time: 0 Render date: 2024-03-28T14:23:30.157Z Has data issue: false hasContentIssue false

A life course perspective on familial and environmental risks for schizophrenia using a western Australian E-cohort

Published online by Cambridge University Press:  23 March 2020

P. Di Prinzio
Affiliation:
The University of Western Australia, School of Psychiatry and Clinical Neurosciences, Perth, Australia
G. Valuri
Affiliation:
The University of Western Australia, School of Psychiatry and Clinical Neurosciences, Perth, Australia
M. Croft
Affiliation:
The University of Western Australia, School of Psychiatry and Clinical Neurosciences, Perth, Australia
S. Shah
Affiliation:
The University of Western Australia, School of Psychiatry and Clinical Neurosciences, Perth, Australia
T. McNeil
Affiliation:
The University of Western Australia, School of Psychiatry and Clinical Neurosciences, Perth, Australia
A. Jablensky
Affiliation:
The University of Western Australia, School of Psychiatry and Clinical Neurosciences, Perth, Australia

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Introduction

Familial risk for psychosis may interact with environmental risk factors.

Objectives

We are studying a large birth cohort of children of mothers with psychotic disorders, themselves at high risk of developing a psychotic illness, to understand the developmental aetiology of psychotic illness.

Aims

Our aim is to examine whether exposure to environmental stressors in childhood, including timing of exposure, is a risk factor for psychotic illness, independent of familial liability. Specificity to maternal schizophrenia is explored.

Methods

We used record-linkage across state-wide registers (midwives, psychiatric, child protection and mortality, among others) to identify 15,486 offspring born in Western Australia 1980–2001 to mothers with a lifetime history of psychotic illness (case children) and compared them with 452,459 offspring born in the same period to mothers with no known psychiatric history (comparison children).

Results

A total of 4.1% of case children had developed a psychotic illness compared to 1.1% of comparison children. Exposure to environmental risk factors including obstetric complications, aboriginality, lower socioeconomic status, discontinuity in parenting and childhood abuse significantly increased risk of psychotic illness in offspring. Length and age at time of discontinuity in parenting impacted on risk. At the same time, case children were also significantly more likely than comparison children to be at risk of experiencing these adverse life events.

Conclusions

Exposure to environmental stressors is associated with psychotic illness, and timing of exposure is important. However, children already at increased familial risk for psychotic illness are also at increased risk of experiencing these environmental stressors.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
S52
Copyright
Copyright © European Psychiatric Association 2016
Submit a response

Comments

No Comments have been published for this article.