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Increased Serum Neurotrophin-4/5 Levels in Bipolar Disorder

Published online by Cambridge University Press:  16 April 2020

J. Walz ,
P.V.d.S. Magalhães ,
L.M. Giglio ,
A.B. Cunha ,
L. Stertz ,
G. Fries ,
A. Andreazza  and
F. Kapczinski
J. Walz
Affiliation:
Molecular Psychiatry Research Unit, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil
P.V.d.S. Magalhães
Affiliation:
Molecular Psychiatry Research Unit, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil
L.M. Giglio
Affiliation:
Molecular Psychiatry Research Unit, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil
A.B. Cunha
Affiliation:
Department of Psychiatry, Universidade Federal de Santa Maria, Santa Maria, Brazil
L. Stertz
Affiliation:
Molecular Psychiatry Research Unit, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil
G. Fries
Affiliation:
Molecular Psychiatry Research Unit, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil
A. Andreazza
Affiliation:
Department of Psychiatry, University of British Columbia, Vancouver, Canada
F. Kapczinski
Affiliation:
Molecular Psychiatry Research Unit, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil

Abstract

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Neurotrophins are central to several aspects of central nervous system function, and emerging evidence links these growth factors to mood disorders. The purpose of this study was to investigate serum neurotrophin-4/5 (NT-4/5) levels in patients with bipolar disorder, both within mood episodes and in euthymia. Patients with bipolar I disorder (n=154) and controls (n=30) had their NT-4/5 serum levels assayed using an ELISA. Levels of NT-4/5 levels were significantly higher in bipolar disorder patients than in controls; NT-4/5 levels were increased in mania, depression and euthymia, but not significantly different between BD mood states. As far as are aware, this is the first study showing NT-4/5 immunocontent alterations in bipolar disorder. A tentative explanation would be that NT-4/5 increases is compensating for ongoing oxidative damage in dopaminergic neurons.

Type
P01-171
Information
European Psychiatry , Volume 24 , Issue S1: 17th EPA Congress - Lisbon, Portugal, January 2009, Abstract book , January 2009 , 24-E559
Copyright
Copyright © European Psychiatric Association 2009
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