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IBZM-SPECT imaging of dopamine D2 receptors with typical and atypical antipsychotics

Published online by Cambridge University Press:  16 April 2020

S Kasper ,
J Tauscher ,
E Küfferle ,
B Hesselmann ,
C Barnas  and
T Brücke
S Kasper
Affiliation:
Department of General Psychiatry, University of Vienna, Wahringer Gurtel 18-20, A-1090
J Tauscher
Affiliation:
Department of General Psychiatry, University of Vienna, Wahringer Gurtel 18-20, A-1090
E Küfferle
Affiliation:
Department of General Psychiatry, University of Vienna, Wahringer Gurtel 18-20, A-1090
B Hesselmann
Affiliation:
Department of General Psychiatry, University of Vienna, Wahringer Gurtel 18-20, A-1090
C Barnas
Affiliation:
Department of General Psychiatry, University of Vienna, Wahringer Gurtel 18-20, A-1090
T Brücke
Affiliation:
Department of General Neurology, University of Vienna, Vienna, Austria
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Summary

Considerable progress has been achieved over the past 15 years in uncovering the biological basis of major psychiatric disorders. Since psychopharmacological treatment is thought tc act on the underlying biological basis of the disease, brain imaging techniques enable us to understand the mechanism of action of such compounds. One important tool used to determine patterns of brain dysfunction and how psychopharmacological agents such as antipsychotic compounds work is single-photon emission computerised tomography (SPECT). This technique allows determination of striatal D2 receptor occupancy rates, which are associated with the extrapyramidal side effects (EPS) of antipsychotic drugs. Studies have confirmed that atypical antipsychotic agents have lower occupancy rates than typical agents. No association has been found between D2 receptor occupancy rates n the striatum and antipsychotic efficacy, and it therefore appears that striatal D2 receptor occupancy rates are not necessary for the antipsychotic effect of such agents in schizophrenia. The availability of more refined radioligands will help us not only to understand the action of antipsychotics but also the pathophysiology of schizophrenia.

Keywords

antipsychoticsschizophreniadopaminereceptorsSPECT
Type
Research Article
Information
European Psychiatry , Volume 13 , Issue S1 , 1998 , pp. 9s - 14s
Copyright
Copyright © Elsevier, Pari 1998

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