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Frontotemporal resting state hypoperfusion in patients with major depression - a study using arterial spin labeling

Published online by Cambridge University Press:  16 April 2020

S. Walther ,
O. Höfle ,
A. Federspiel ,
H. Horn ,
W. Strik  and
T.J. Müller
S. Walther
Affiliation:
University Hospital of Psychiatry, University of Bern, Bern, Switzerland
O. Höfle
Affiliation:
University Hospital of Psychiatry, University of Bern, Bern, Switzerland
A. Federspiel
Affiliation:
University Hospital of Psychiatry, University of Bern, Bern, Switzerland
H. Horn
Affiliation:
University Hospital of Psychiatry, University of Bern, Bern, Switzerland
W. Strik
Affiliation:
University Hospital of Psychiatry, University of Bern, Bern, Switzerland
T.J. Müller
Affiliation:
University Hospital of Psychiatry, University of Bern, Bern, Switzerland

Abstract

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Introduction

Major depression is associated with altered neural function in frontal and limbic areas.

Objectives

The findings have been inconsistent, especially those derived from cerebral blood flow (CBF) measures.

Aims

To identify differences in regional CBF between patients and controls using arterial spin labeling (ASL) at rest.

Methods

20 patients with major depression and 20 matched healthy controls were scanned in the morning with a pCASL-sequence at a 3 T Siemens scanner. Mean Hamilton Depression Score (21 item version) was 26.2 ± 5.7 for patients, mean Beck Depression Inventory scores were 28.9 ± 8.9. Mean age did not differ between groups (39.6 vs. 44.4 years). Whole brain voxelwise T-Tests were correct for multiple comparisons using a False Discovery Rate of q < 0.05.

Results

Mean global resting CBF was not different between groups (66.1 vs. 63.0 ml/100 mg/min, T = 0.95, p = 0.35). FDR correction at q < 0.05 led to a T-value threshold of 3.71 (p < 0.001) for group comparison. Hypoperfusion in patients was detected in left middle temporal gyrus, left middle frontal gyrus, right precentral gyrus. Hyperperfusion in patients was seen in the right superior temporal gyrus.

Conclusions

ASL revealed frontotemporal hypoperfusion in patients with major depression. This is in line with previous work and the current concept of depression. However, we were unable to replicate hyperperfusion in limibic areas.

Type
P02-365
Information
European Psychiatry , Volume 26 , Issue S2: Abstracts of the 19th European Congress of Psychiatry , March 2011 , pp. 961
Copyright
Copyright © European Psychiatric Association 2011
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